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Mep1b meprin 1 beta [ Mus musculus (house mouse) ]

Gene ID: 17288, updated on 1-Mar-2024

Summary

Official Symbol
Mep1bprovided by MGI
Official Full Name
meprin 1 betaprovided by MGI
Primary source
MGI:MGI:96964
See related
Ensembl:ENSMUSG00000024313 AllianceGenome:MGI:96964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mep-1b
Summary
Predicted to enable identical protein binding activity and metalloendopeptidase activity. Acts upstream of or within toxin transport. Located in membrane. Is expressed in early distal tubule; early proximal tubule; intestine; intestine epithelium; and metanephros. Orthologous to human MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 195.8), small intestine adult (RPKM 74.1) and 2 other tissues See more
Orthologs
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Genomic context

See Mep1b in Genome Data Viewer
Location:
18 A2; 18 11.81 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (21205401..21233256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (21072344..21100199)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997 Neighboring gene STARR-positive B cell enhancer ABC_E3224 Neighboring gene STARR-seq mESC enhancer starr_43999 Neighboring gene ring finger protein 138 Neighboring gene STARR-seq mESC enhancer starr_44001 Neighboring gene STARR-seq mESC enhancer starr_44006 Neighboring gene STARR-seq mESC enhancer starr_44007 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene STARR-seq mESC enhancer starr_44011 Neighboring gene predicted gene 7758

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC159330

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of meprin A complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
meprin A subunit beta
Names
endopeptidase-2
meprin B
meprin beta
NP_032612.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008586.2NP_032612.2  meprin A subunit beta precursor

    See identical proteins and their annotated locations for NP_032612.2

    Status: VALIDATED

    Source sequence(s)
    AK098127
    Consensus CDS
    CCDS37747.1
    UniProtKB/Swiss-Prot
    Q059K0, Q61847
    Related
    ENSMUSP00000080866.5, ENSMUST00000082235.5
    Conserved Domains (6) summary
    cd06263
    Location:266428
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cd00054
    Location:609647
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00629
    Location:266430
    MAM; MAM domain, meprin/A5/mu
    pfam01400
    Location:70258
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:30256
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    cl02446
    Location:428587
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    21205401..21233256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)