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MEP1B meprin A subunit beta [ Homo sapiens (human) ]

Gene ID: 4225, updated on 5-Jul-2020

Summary

Official Symbol
MEP1Bprovided by HGNC
Official Full Name
meprin A subunit betaprovided by HGNC
Primary source
HGNC:HGNC:7020
See related
Ensembl:ENSG00000141434 MIM:600389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]
Expression
Biased expression in small intestine (RPKM 150.9) and duodenum (RPKM 98.0) See more
Orthologs

Genomic context

See MEP1B in Genome Data Viewer
Location:
18q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (32190039..32222607)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29769987..29800367)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 138 Neighboring gene RNA, 5S ribosomal pseudogene 453 Neighboring gene clustered mitochondria homolog pseudogene 6 Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 7 Neighboring gene WBP11 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
meprin A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meprin A subunit beta
Names
N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta
N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit
PABA peptide hydrolase
PPH beta
endopeptidase-2
meprin A, beta
meprin B
NP_001295100.1
NP_005916.2
XP_011524315.1
XP_011524316.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308171.2NP_001295100.1  meprin A subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001295100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC011825, AC015563, X81333
    Consensus CDS
    CCDS77173.1
    UniProtKB/Swiss-Prot
    Q16820
    UniProtKB/TrEMBL
    J3QKX5
    Related
    ENSP00000463280.1, ENST00000581447.1
    Conserved Domains (5) summary
    cd06263
    Location:265427
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:260427
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd04282
    Location:26255
    ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
    pfam01400
    Location:69257
    Astacin; Astacin (Peptidase family M12A)
    cl02446
    Location:427586
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
  2. NM_005925.3NP_005916.2  meprin A subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_005916.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY695931, X81333
    Consensus CDS
    CCDS45846.1
    UniProtKB/Swiss-Prot
    Q16820
    Related
    ENSP00000269202.6, ENST00000269202.11
    Conserved Domains (5) summary
    cd06263
    Location:265427
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:260427
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd04282
    Location:26255
    ZnMc_meprin; Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as ...
    pfam01400
    Location:69257
    Astacin; Astacin (Peptidase family M12A)
    cl02446
    Location:427586
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    32190039..32222607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526013.2XP_011524315.1  meprin A subunit beta isoform X1

    Conserved Domains (4) summary
    cd06263
    Location:192354
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:187354
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd03782
    Location:354513
    MATH_Meprin_Beta; Meprin family, Beta subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
    cl00064
    Location:26188
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_011526014.2XP_011524316.1  meprin A subunit beta isoform X2

    Conserved Domains (5) summary
    cd06263
    Location:182303
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00235
    Location:70197
    ZnMc; Zinc-dependent metalloprotease
    cd00054
    Location:482520
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd03782
    Location:303462
    MATH_Meprin_Beta; Meprin family, Beta subunit, MATH domain; Meprins are multidomain extracellular metalloproteases capable of cleaving growth factors, cytokines, extracellular matrix proteins, and biologically active peptides. They are composed of two related subunits, ...
    cl00064
    Location:26215
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
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