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Mef2c myocyte enhancer factor 2C [ Mus musculus (house mouse) ]

Gene ID: 17260, updated on 24-Dec-2019

Summary

Official Symbol
Mef2cprovided by MGI
Official Full Name
myocyte enhancer factor 2Cprovided by MGI
Primary source
MGI:MGI:99458
See related
Ensembl:ENSMUSG00000005583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mef2; AV011172; 5430401D19Rik; 9930028G15Rik
Expression
Biased expression in cortex adult (RPKM 49.3), frontal lobe adult (RPKM 37.4) and 11 other tissues See more
Orthologs

Genomic context

See Mef2c in Genome Data Viewer
Location:
13 C3; 13 43.68 cM
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (83504017..83667079)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (83643033..83806684)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33274 Neighboring gene predicted gene, 33317 Neighboring gene VISTA enhancer mm1175 Neighboring gene predicted gene, 52043 Neighboring gene predicted gene, 52044 Neighboring gene RIKEN cDNA C130071C03 gene Neighboring gene predicted gene, 52046 Neighboring gene predicted gene, 51268 Neighboring gene microRNA 9-2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AT DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
HMG box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac ventricle formation IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac ventricle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to parathyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to trichostatin A IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endochondral ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell proliferation involved in renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alkaline phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation in bone marrow IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
primary heart field specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
secondary heart field specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
sinoatrial valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
sarcomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myocyte-specific enhancer factor 2C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170537.1NP_001164008.1  myocyte-specific enhancer factor 2C isoform 1

    See identical proteins and their annotated locations for NP_001164008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region, compared to variant 3, resulting in an isoform (1) that is shorter than isoform 3.
    Source sequence(s)
    AK132573, CJ155464, CT025631, CU074400
    Consensus CDS
    CCDS49320.1
    UniProtKB/TrEMBL
    Q3V1B5
    Related
    ENSMUSP00000143315.1, ENSMUST00000199450.4
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. NM_001347564.1NP_001334493.1  myocyte-specific enhancer factor 2C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3). Variants 3, 4 and 5 all encode isoform 3.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84042.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  3. NM_001347566.1NP_001334495.1  myocyte-specific enhancer factor 2C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3, 4 and 5 all encode isoform 3.
    Source sequence(s)
    AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84042.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    Related
    ENSMUSP00000143401.1, ENSMUST00000199019.4
  4. NM_001347567.1NP_001334496.1  myocyte-specific enhancer factor 2C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 3, 4 and 5 all encode isoform 3.
    Source sequence(s)
    AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84042.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    Related
    ENSMUSP00000143212.1, ENSMUST00000199105.4
  5. NM_001347568.1NP_001334497.1  myocyte-specific enhancer factor 2C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame exon in the 5' coding region, compared to variant 3. The encoded isoform (4) is shorter than isoform 3. Both variants 6 and 7 encode isoform 4.
    Source sequence(s)
    AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84045.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  6. NM_001347569.1NP_001334498.1  myocyte-specific enhancer factor 2C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame exon in the 5' coding region, compared to variant 3. The encoded isoform (4) is shorter than isoform 3. Both variants 6 and 7 encode isoform 4.
    Source sequence(s)
    AI645159, AK009139, AK132573, BB642670, CK781244, CT025631, CU074400
    Consensus CDS
    CCDS84045.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    UniProtKB/TrEMBL
    Q3V1B5
    Related
    ENSMUSP00000138826.2, ENSMUST00000185052.5
  7. NM_001347571.1NP_001334500.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  8. NM_001347572.1NP_001334501.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  9. NM_001347573.1NP_001334502.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  10. NM_001347574.1NP_001334503.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  11. NM_001347575.1NP_001334504.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
  12. NM_001347576.1NP_001334505.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AI645159, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    Related
    ENSMUSP00000143420.1, ENSMUST00000197681.4
  13. NM_001347577.1NP_001334506.1  myocyte-specific enhancer factor 2C isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3, resulting in an isoform (5) that is shorter than isoform 3. Variants 8 through 14 all encode isoform 5.
    Source sequence(s)
    AI645159, AK132573, BB642670, CK781244, CT025631, CU074400
    Consensus CDS
    CCDS84043.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    UniProtKB/TrEMBL
    Q3V1B5
    Related
    ENSMUSP00000143227.1, ENSMUST00000197146.4
  14. NM_001347578.1NP_001334507.1  myocyte-specific enhancer factor 2C isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, lacks an in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (6) is shorter than isoform 3.
    Source sequence(s)
    AI645159, AK077603, AK132573, CT025631, CU074400
    Consensus CDS
    CCDS84044.1
    UniProtKB/TrEMBL
    A0A0G2JEC2, Q3V1B5
    Related
    ENSMUSP00000142714.1, ENSMUST00000199432.4
  15. NM_001347579.1NP_001334508.1  myocyte-specific enhancer factor 2C isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (7) has a distinct C-terminus and is shorter than isoform 3. Both variants 16 and 17 encode isoform 7.
    Source sequence(s)
    AC107750, AI645159, CT025631, CU074400
  16. NM_001347580.1NP_001334509.1  myocyte-specific enhancer factor 2C isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (7) has a distinct C-terminus and is shorter than isoform 3. Both variants 16 and 17 encode isoform 7.
    Source sequence(s)
    AI645159, CT025631, CU074400
  17. NM_001347581.1NP_001334510.1  myocyte-specific enhancer factor 2C isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR, lacks an in-frame exon in the central coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (8) has a distinct C-terminus and is shorter than isoform 3.
    Source sequence(s)
    AI645159, CT025631, CU074400
  18. NM_025282.3NP_079558.1  myocyte-specific enhancer factor 2C isoform 2

    See identical proteins and their annotated locations for NP_079558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region, lacks an in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AK009139, CJ155464, CT025631, CU074400
    Consensus CDS
    CCDS26664.1
    UniProtKB/Swiss-Prot
    Q8CFN5
    Related
    ENSMUSP00000143742.1, ENSMUST00000198199.4
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    83504017..83667079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517123.3XP_006517186.1  myocyte-specific enhancer factor 2C isoform X1

    See identical proteins and their annotated locations for XP_006517186.1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. XM_030247172.1XP_030103032.1  myocyte-specific enhancer factor 2C isoform X1

  3. XM_017315405.2XP_017170894.1  myocyte-specific enhancer factor 2C isoform X1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  4. XM_011244495.3XP_011242797.1  myocyte-specific enhancer factor 2C isoform X8

    UniProtKB/TrEMBL
    A0A0H2UH28
    Related
    ENSMUSP00000132547.2, ENSMUST00000163888.7
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:116171
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  5. XM_006517128.4XP_006517191.1  myocyte-specific enhancer factor 2C isoform X3

    UniProtKB/TrEMBL
    A0A0H2UKB6
    Related
    ENSMUSP00000005722.8, ENSMUST00000005722.13
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  6. XM_030247173.1XP_030103033.1  myocyte-specific enhancer factor 2C isoform X3

  7. XM_030247174.1XP_030103034.1  myocyte-specific enhancer factor 2C isoform X3

    Related
    ENSMUSP00000142487.1, ENSMUST00000198217.4
  8. XM_006517126.3XP_006517189.1  myocyte-specific enhancer factor 2C isoform X2

    See identical proteins and their annotated locations for XP_006517189.1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  9. XM_006517132.4XP_006517195.1  myocyte-specific enhancer factor 2C isoform X5

    See identical proteins and their annotated locations for XP_006517195.1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  10. XM_006517127.4XP_006517190.1  myocyte-specific enhancer factor 2C isoform X4

    See identical proteins and their annotated locations for XP_006517190.1

    UniProtKB/TrEMBL
    Q3V1B5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  11. XM_030247175.1XP_030103035.1  myocyte-specific enhancer factor 2C isoform X4

  12. XM_030247176.1XP_030103036.1  myocyte-specific enhancer factor 2C isoform X4

  13. XM_006517124.4XP_006517187.1  myocyte-specific enhancer factor 2C isoform X1

    See identical proteins and their annotated locations for XP_006517187.1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  14. XM_006517130.3XP_006517193.1  myocyte-specific enhancer factor 2C isoform X7

    See identical proteins and their annotated locations for XP_006517193.1

    UniProtKB/TrEMBL
    A0A0G2JEC2
    Related
    ENSMUSP00000142456.1, ENSMUST00000197722.4
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  15. XM_030247177.1XP_030103037.1  myocyte-specific enhancer factor 2C isoform X6

    Related
    ENSMUSP00000142595.1, ENSMUST00000199210.4
  16. XM_011244492.3XP_011242794.1  myocyte-specific enhancer factor 2C isoform X1

    See identical proteins and their annotated locations for XP_011242794.1

    UniProtKB/Swiss-Prot
    Q8CFN5
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107153
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
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