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Mea1 male enhanced antigen 1 [ Mus musculus (house mouse) ]

Gene ID: 17256, updated on 2-Nov-2024

Summary

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Official Symbol
Mea1provided by MGI
Official Full Name
male enhanced antigen 1provided by MGI
Primary source
MGI:MGI:96957
See related
Ensembl:ENSMUSG00000002768 AllianceGenome:MGI:96957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mea-1
Summary
Predicted to be involved in cell differentiation and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MEA1 (male-enhanced antigen 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 378.2), CNS E18 (RPKM 37.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Mea1 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46989699..46994052)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46678801..46683126)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene kelch domain containing 3 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Lau YF, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2813404, Free PMC Article
  2. Cloning and sequence analysis of cDNA encoding the bovine testis-derived male-enhanced antigen (Mea). Kondo M, et al. Biochim Biophys Acta, 1993 Dec 14. PMID 8268232
  3. Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. Ortega-Lázaro JC, et al. Cytogenet Genome Res, 2003. PMID 15051958
  4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
  5. High-resolution comparative mapping of mouse chromosome 17. Himmelbauer H, et al. Genomics, 1993 Jul. PMID 8406442

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. localization of the male-enhanced antigen-1 suggests that it may function in the very late stages of spermiogenesis
    Title: Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis.
  2. A comparative expression study of Mea1 and the B56delta subunit of protein phosphatase 2A in spermatogenesis.
    Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
male-enhanced antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277309.1 → NP_001264238.1  male-enhanced antigen 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK010904, BY510335, BY707372, CT030702
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Conserved Domains (1) summary
    pfam06910
    Location:42 → 215
    MEA1; Male enhanced antigen 1 (MEA1)

  2. NM_001277310.1 → NP_001264239.1  male-enhanced antigen 1 isoform b

    See identical proteins and their annotated locations for NP_001264239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AK010904, BG085669, BY510335, CT030702
    Consensus CDS
    CCDS28835.1
    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Related
    ENSMUSP00000156392.2, ENSMUST00000232732.2
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)

  3. NM_001277311.1 → NP_001264240.1  male-enhanced antigen 1 isoform b

    See identical proteins and their annotated locations for NP_001264240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AK010904, BY510335, CT030702
    Consensus CDS
    CCDS28835.1
    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Related
    ENSMUSP00000156895.2, ENSMUST00000232762.2
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)

  4. NM_001277312.1 → NP_001264241.1  male-enhanced antigen 1 isoform b

    See identical proteins and their annotated locations for NP_001264241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AK010904, BY510335, CT030702
    Consensus CDS
    CCDS28835.1
    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Related
    ENSMUSP00000156967.2, ENSMUST00000233612.2
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)

  5. NM_001413530.1 → NP_001400459.1  male-enhanced antigen 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    CT030702
    UniProtKB/Swiss-Prot
    Q64327, Q793G4

  6. NM_001413531.1 → NP_001400460.1  male-enhanced antigen 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    CT030702
    UniProtKB/Swiss-Prot
    Q64327, Q793G4

  7. NM_001413532.1 → NP_001400461.1  male-enhanced antigen 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    CT030702

  8. NM_001413533.1 → NP_001400462.1  male-enhanced antigen 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    CT030702

  9. NM_001413534.1 → NP_001400463.1  male-enhanced antigen 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    CT030702

  10. NM_001413536.1 → NP_001400465.1  male-enhanced antigen 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    CT030702

  11. NM_010787.2 → NP_034917.1  male-enhanced antigen 1 isoform b

    See identical proteins and their annotated locations for NP_034917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AK010904, BY510335, CJ042312
    Consensus CDS
    CCDS28835.1
    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Related
    ENSMUSP00000002845.7, ENSMUST00000002845.8
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)

RNA

  1. NR_102392.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK008194, BY510335, CJ042312, CT030702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46989699..46994052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523748.4 → XP_006523811.1  male-enhanced antigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006523811.1

    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)

  2. XM_006523750.5 → XP_006523813.1  male-enhanced antigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006523813.1

    UniProtKB/Swiss-Prot
    Q64327, Q793G4
    UniProtKB/TrEMBL
    A0A3B2WB12, Q9D0Q0, Q9DB93
    Conserved Domains (1) summary
    pfam06910
    Location:54 → 170
    MEA1; Male enhanced antigen 1 (MEA1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64327.1 GenPept UniProtKB/Swiss-Prot:Q64327

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