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MEA1 male-enhanced antigen 1 [ Homo sapiens (human) ]

Gene ID: 4201, updated on 7-Jun-2020

Summary

Official Symbol
MEA1provided by HGNC
Official Full Name
male-enhanced antigen 1provided by HGNC
Primary source
HGNC:HGNC:6986
See related
Ensembl:ENSG00000124733 MIM:143170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYS; MEA
Expression
Broad expression in testis (RPKM 41.1), brain (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See MEA1 in Genome Data Viewer
Location:
6p21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (42980344..43017086, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42948082..42981947, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CNPY3-GNMT readthrough Neighboring gene RPL24 pseudogene 4 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene kelch domain containing 3 Neighboring gene ribosomal RNA processing 36 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
male gonad development TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
male-enhanced antigen 1
Names
Male-enhanced antigen (H-Y structural gene)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318942.1NP_001305871.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM450289, BM969076, HY039733
    Consensus CDS
    CCDS87405.1
    Related
    ENSP00000493896.1, ENST00000643776.1
    Conserved Domains (1) summary
    pfam06910
    Location:1172
    MEA1; Male enhanced antigen 1 (MEA1)
  2. NM_001318943.1NP_001305872.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM552852, BM969076, DB451970
    Consensus CDS
    CCDS87405.1
    Related
    ENSP00000494198.1, ENST00000645410.1
    Conserved Domains (1) summary
    pfam06910
    Location:1172
    MEA1; Male enhanced antigen 1 (MEA1)
  3. NM_001363578.1NP_001350507.1  male-enhanced antigen 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL136304
    Consensus CDS
    CCDS87406.1
    Related
    ENSP00000495612.1, ENST00000642748.1
    Conserved Domains (1) summary
    pfam06910
    Location:17188
    MEA1; Male enhanced antigen 1 (MEA1)
  4. NM_014623.4NP_055438.1  male-enhanced antigen 1 isoform 1

    See identical proteins and their annotated locations for NP_055438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL136304, BM969076, BQ232807
    Consensus CDS
    CCDS4879.1
    UniProtKB/Swiss-Prot
    Q16626
    Related
    ENSP00000244711.3, ENST00000244711.4
    Conserved Domains (1) summary
    pfam06910
    Location:14185
    MEA1; Male enhanced antigen 1 (MEA1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    42980344..43017086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010868.1XP_016866357.1  male-enhanced antigen 1 isoform X3

  2. XM_024446445.1XP_024302213.1  male-enhanced antigen 1 isoform X2

    Related
    ENSP00000493661.1, ENST00000645375.1
    Conserved Domains (1) summary
    pfam06910
    Location:1172
    MEA1; Male enhanced antigen 1 (MEA1)
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