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MEA1 male-enhanced antigen 1 [ Homo sapiens (human) ]

Gene ID: 4201, updated on 12-Aug-2022

Summary

Official Symbol
MEA1provided by HGNC
Official Full Name
male-enhanced antigen 1provided by HGNC
Primary source
HGNC:HGNC:6986
See related
Ensembl:ENSG00000124733 MIM:143170; AllianceGenome:HGNC:6986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYS; MEA
Summary
Predicted to be involved in male gonad development. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 41.1), brain (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See MEA1 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43011143..43016886, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42840241..42845985, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42978881..42984624, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900215 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene Sharpr-MPRA regulatory region 14905 Neighboring gene kelch domain containing 3 Neighboring gene ribosomal RNA processing 36 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
male-enhanced antigen 1
Names
Male-enhanced antigen (H-Y structural gene)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318942.1NP_001305871.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM450289, BM969076, HY039733
    Consensus CDS
    CCDS87405.1
    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000493896.1, ENST00000643776.1
    Conserved Domains (1) summary
    pfam06910
    Location:53168
    MEA1; Male enhanced antigen 1 (MEA1)
  2. NM_001318943.1NP_001305872.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM552852, BM969076, DB451970
    Consensus CDS
    CCDS87405.1
    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000494198.1, ENST00000645410.1
    Conserved Domains (1) summary
    pfam06910
    Location:53168
    MEA1; Male enhanced antigen 1 (MEA1)
  3. NM_001363578.1NP_001350507.1  male-enhanced antigen 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL136304
    Consensus CDS
    CCDS87406.1
    UniProtKB/TrEMBL
    A0A2R8Y6W5
    Related
    ENSP00000495612.1, ENST00000642748.1
    Conserved Domains (1) summary
    pfam06910
    Location:69184
    MEA1; Male enhanced antigen 1 (MEA1)
  4. NM_014623.4NP_055438.1  male-enhanced antigen 1 isoform 1

    See identical proteins and their annotated locations for NP_055438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL136304, BM969076, BQ232807
    Consensus CDS
    CCDS4879.1
    UniProtKB/Swiss-Prot
    Q16626, Q9BV01
    Related
    ENSP00000244711.3, ENST00000244711.4
    Conserved Domains (1) summary
    pfam06910
    Location:66181
    MEA1; Male enhanced antigen 1 (MEA1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43011143..43016886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446445.2XP_024302213.1  male-enhanced antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000493661.1, ENST00000645375.1
    Conserved Domains (1) summary
    pfam06910
    Location:53168
    MEA1; Male enhanced antigen 1 (MEA1)
  2. XM_047418782.1XP_047274738.1  male-enhanced antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000496447.1, ENST00000642555.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42840241..42845985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)