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ccpp-1 Cytosolic carboxypeptidase 1 [ Caenorhabditis elegans ]

Gene ID: 172241, updated on 23-Nov-2023

Summary

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Gene symbol
ccpp-1
Gene description
Cytosolic carboxypeptidase 1
Primary source
WormBase:WBGene00018995
Locus tag
CELE_F56H1.5
See related
AllianceGenome:WB:WBGene00018995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Involved in oviposition. Predicted to be located in cilium; dendrite; and perikaryon. Is expressed in gubernacular muscle and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to several human genes including AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
18
Sequence:
Chromosome: I; NC_003279.8 (5754312..5760799, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Reticulon-4-interacting protein 1, mitochondrial Neighboring gene SSD domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Palmitoyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia. O'Hagan R, et al. Curr Biol, 2017 Nov 20. PMID 29129530, Free PMC Article
  2. The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans. O'Hagan R, et al. Curr Biol, 2011 Oct 25. PMID 21982591, Free PMC Article
  3. Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. Harris A, et al. Mol Cell Neurosci, 2000 Nov. PMID 11083920
  4. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function. Power KM, et al. PLoS Genet, 2020 Oct. PMID 33064774, Free PMC Article
  5. Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs). Kimura Y, et al. J Biol Chem, 2010 Jul 23. PMID 20519502, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCPP-1 acts as a tubulin deglutamylase that regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia of a multicellular, living animal.
    Title: The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.
  2. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
    Title: Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C-terminal protein deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein side chain deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cytosolic carboxypeptidase 1
NP_491674.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5754312..5760799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059273.7 → NP_491674.2  Cytosolic carboxypeptidase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491674.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76373
    Conserved Domains (1) summary
    cd06235
    Location:738 → 1011
    M14_Nna1_like_2; Peptidase M14-like domain of human Nna1/AGTPBP-1, AGBL2 -5, and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76373.2

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