Anapc1 anaphase promoting complex subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anapc1provided by MGI
Official Full Name: anaphase promoting complex subunit 1provided by MGI
Primary source: MGI:MGI:103097
See related: Ensembl:ENSMUSG00000014355 AllianceGenome:MGI:103097
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apc1; Mcpr; tsg24; 2610021O03Rik
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in nucleus. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 F1

Exon count:: 50

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (128452003..128529558, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (128610083..128687406, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.
Title: The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact.
Title: The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW547281 (e-PCR)
- UniSTS:178704

AI853536 (e-PCR)
- UniSTS:178705

NoName (e-PCR)
- UniSTS:234522

X80169 (e-PCR)
- UniSTS:125857

RH135847 (e-PCR)
- UniSTS:209845

Homology

Homologs of the Anapc1 gene: The Anapc1 gene is conserved in human, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 479 organisms have orthologs with human gene Anapc1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: anaphase-promoting complex subunit 1

Names: cyclosome subunit 1; meiotic check point regulator; mitotic checkpoint regulator; testis-specific gene 24 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008569.2 → NP_032595.2 anaphase-promoting complex subunit 1

See identical proteins and their annotated locations for NP_032595.2

Status: VALIDATED

Source sequence(s)

AK034858, AK077847, BB676785, BC139002, BE987509

Consensus CDS

CCDS16715.1

UniProtKB/Swiss-Prot

P53995, Q8C772

Related

ENSMUSP00000014499.4, ENSMUST00000014499.10

Conserved Domains (2) summary

pfam01851
Location:1467 → 1501

PC_rep; Proteasome/cyclosome repeat

pfam12859
Location:150 → 218

ANAPC1; Anaphase-promoting complex subunit 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

128452003..128529558 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248086.2 → XP_030103946.1 anaphase-promoting complex subunit 1 isoform X1

Conserved Domains (2) summary

pfam01851
Location:1349 → 1383

PC_rep; Proteasome/cyclosome repeat

pfam18122
Location:1618 → 1777

APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain
XM_011239332.4 → XP_011237634.1 anaphase-promoting complex subunit 1 isoform X2

Related

ENSMUSP00000105962.2, ENSMUST00000110333.2

Conserved Domains (1) summary

pfam12859
Location:150 → 218

ANAPC1; Anaphase-promoting complex subunit 1