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ANAPC1 anaphase promoting complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 64682, updated on 5-Dec-2021

Summary

Official Symbol
ANAPC1provided by HGNC
Official Full Name
anaphase promoting complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:19988
See related
Ensembl:ENSG00000153107 MIM:608473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC1; MCPR; TSG24
Summary
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

See ANAPC1 in Genome Data Viewer
Location:
2q13
Exon count:
50
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (111766150..111884196, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (112525217..112641770, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6320 Neighboring gene CENPN pseudogene 2 Neighboring gene microRNA 4771-2 Neighboring gene eukaryotic translation elongation factor 1 epsilon 1 pseudogene 1 Neighboring gene MER proto-oncogene, tyrosine kinase Neighboring gene RNA, 7SL, cytoplasmic 297, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available
Rothmund-Thomson syndrome type 1
MedGen: C5231433 OMIM: 618625 GeneReviews: Rothmund-Thomson Syndrome
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with anaphase promoting complex subunit 1 (APC1; ANAPC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 1
Names
anaphase-promoting complex 1 (meiotic checkpoint regulator)
cyclosome subunit 1
mitotic checkpoint regulator
testis-specific gene 24 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022662.4NP_073153.1  anaphase-promoting complex subunit 1

    See identical proteins and their annotated locations for NP_073153.1

    Status: VALIDATED

    Source sequence(s)
    AC093166, AC104651
    Consensus CDS
    CCDS2093.1
    UniProtKB/Swiss-Prot
    Q9H1A4
    Related
    ENSP00000339109.3, ENST00000341068.8
    Conserved Domains (3) summary
    pfam01851
    Location:14671501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150206
    ANAPC1; Anaphase-promoting complex subunit 1
    pfam18122
    Location:17391895
    APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    111766150..111884196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004710.2XP_016860199.1  anaphase-promoting complex subunit 1 isoform X2

  2. XM_017004711.1XP_016860200.1  anaphase-promoting complex subunit 1 isoform X3

  3. XM_011511633.2XP_011509935.1  anaphase-promoting complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01851
    Location:14711505
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150206
    ANAPC1; Anaphase-promoting complex subunit 1
  4. XM_017004713.1XP_016860202.1  anaphase-promoting complex subunit 1 isoform X6

    Conserved Domains (2) summary
    pfam01851
    Location:13111345
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:246
    ANAPC1; Anaphase-promoting complex subunit 1
  5. XM_011511634.2XP_011509936.1  anaphase-promoting complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam01851
    Location:13731407
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:52108
    ANAPC1; Anaphase-promoting complex subunit 1
  6. XM_017004712.2XP_016860201.1  anaphase-promoting complex subunit 1 isoform X5

  7. XM_017004714.1XP_016860203.1  anaphase-promoting complex subunit 1 isoform X7

    Related
    ENSP00000396695.1, ENST00000427997.5
  8. XM_017004715.1XP_016860204.1  anaphase-promoting complex subunit 1 isoform X8

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