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Mapkapk5 MAP kinase-activated protein kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 17165, updated on 8-Feb-2024

Summary

Official Symbol
Mapkapk5provided by MGI
Official Full Name
MAP kinase-activated protein kinase 5provided by MGI
Primary source
MGI:MGI:1333110
See related
Ensembl:ENSMUSG00000029454 AllianceGenome:MGI:1333110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MK5; PRAK
Summary
Enables mitogen-activated protein kinase binding activity; p53 binding activity; and protein serine/threonine kinase activity. Involved in Ras protein signal transduction; negative regulation of TOR signaling; and stress-induced premature senescence. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in brain; embryo; and lung. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.0), CNS E14 (RPKM 20.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mapkapk5 in Genome Data Viewer
Location:
5 F; 5 61.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121663114..121683955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121525051..121545892, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092 Neighboring gene STARR-positive B cell enhancer ABC_E11301 Neighboring gene STARR-seq mESC enhancer starr_14260 Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Adam1a

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in septin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MAP kinase-activated protein kinase 5
Names
MAPK-activated protein kinase 5
MAPKAP kinase 5
MAPKAPK-5
NP_034895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010765.2NP_034895.1  MAP kinase-activated protein kinase 5

    See identical proteins and their annotated locations for NP_034895.1

    Status: VALIDATED

    Source sequence(s)
    AF039840, BY722898
    Consensus CDS
    CCDS39248.1
    UniProtKB/Swiss-Prot
    E9QQ45, O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7
    UniProtKB/TrEMBL
    A0A0G2JDU2
    Related
    ENSMUSP00000031410.8, ENSMUST00000031410.14
    Conserved Domains (1) summary
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121663114..121683955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)