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MAPKAPK5 MAPK activated protein kinase 5 [ Homo sapiens (human) ]

Gene ID: 8550, updated on 5-Sep-2021

Summary

Official Symbol
MAPKAPK5provided by HGNC
Official Full Name
MAPK activated protein kinase 5provided by HGNC
Primary source
HGNC:HGNC:6889
See related
Ensembl:ENSG00000089022 MIM:606723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MK5; MK-5; PRAK; MAPKAP-K5
Summary
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See MAPKAPK5 in Genome Data Viewer
Location:
12q24.12-q24.13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (111842228..111902222)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112280032..112340026)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family member 10 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene microRNA 6761 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene transmembrane protein 116 Neighboring gene ADAM metallopeptidase domain 1A (pseudogene) Neighboring gene ADAM metallopeptidase domain 1B (pseudogene) Neighboring gene solute carrier family 25 member 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular senescence TAS
Traceable Author Statement
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in stress-induced premature senescence IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP kinase-activated protein kinase 5
Names
MAPKAP kinase 5
MAPKAPK-5
mitogen-activated protein kinase-activated protein kinase 5
p38-regulated/activated protein kinase
NP_001358408.1
NP_001358409.1
NP_001358410.1
NP_001358411.1
NP_001358412.1
NP_001358413.1
NP_001358414.1
NP_001358415.1
NP_001358416.1
NP_003659.2
NP_620777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371479.1NP_001358408.1  MAP kinase-activated protein kinase 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  2. NM_001371480.1NP_001358409.1  MAP kinase-activated protein kinase 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  3. NM_001371481.1NP_001358410.1  MAP kinase-activated protein kinase 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15277
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001371482.1NP_001358411.1  MAP kinase-activated protein kinase 5 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15274
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001371483.1NP_001358412.1  MAP kinase-activated protein kinase 5 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15274
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001371484.1NP_001358413.1  MAP kinase-activated protein kinase 5 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15270
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001371485.1NP_001358414.1  MAP kinase-activated protein kinase 5 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15235
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001371486.1NP_001358415.1  MAP kinase-activated protein kinase 5 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Conserved Domains (1) summary
    cl21453
    Location:15235
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001371487.1NP_001358416.1  MAP kinase-activated protein kinase 5 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Related
    ENSP00000473467.1, ENST00000549875.1
    Conserved Domains (1) summary
    cl21453
    Location:15205
    PKc_like; Protein Kinases, catalytic domain
  10. NM_003668.4NP_003659.2  MAP kinase-activated protein kinase 5 isoform 1

    See identical proteins and their annotated locations for NP_003659.2

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Consensus CDS
    CCDS44976.1
    UniProtKB/Swiss-Prot
    Q8IW41
    Related
    ENSP00000449667.2, ENST00000550735.7
    Conserved Domains (1) summary
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5
  11. NM_139078.3NP_620777.1  MAP kinase-activated protein kinase 5 isoform 2

    See identical proteins and their annotated locations for NP_620777.1

    Status: REVIEWED

    Source sequence(s)
    AC003029
    Consensus CDS
    CCDS44975.1
    UniProtKB/Swiss-Prot
    Q8IW41
    Related
    ENSP00000449381.2, ENST00000551404.6
    Conserved Domains (1) summary
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    111842228..111902222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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