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Hdac10 histone deacetylase 10 [ Mus musculus (house mouse) ]

Gene ID: 170787, updated on 2-Nov-2024

Summary

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Official Symbol
Hdac10provided by MGI
Official Full Name
histone deacetylase 10provided by MGI
Primary source
MGI:MGI:2158340
See related
Ensembl:ENSMUSG00000062906 AllianceGenome:MGI:2158340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hd10
Summary
Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of mismatch repair; regulation of gene expression; and spermidine deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 30.7), thymus adult (RPKM 25.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hdac10 in Genome Data Viewer
Location:
15 E3; 15 44.64 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89007506..89012903, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89123303..89128700, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165. Xiang Y, et al. Respir Res, 2024 Jul 2. PMID 38956592, Free PMC Article
  2. Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. Zhou W, et al. Sci Signal, 2022 Dec 20. PMID 36538592
  3. HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. Li Y, et al. Cancer Res, 2020 Aug 15. PMID 32540961, Free PMC Article
  4. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. Liu F, et al. J Mol Cell Cardiol, 2008 Dec. PMID 18926829, Free PMC Article
  5. HDAC10 deletion promotes Foxp3(+) T-regulatory cell function. Dahiya S, et al. Sci Rep, 2020 Jan 16. PMID 31949209, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
    Title: Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
  2. Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
    Title: Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
  3. HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
    Title: HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
  4. HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.
    Title: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylputrescine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylspermidine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein lysine deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in polyamine deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in polyamine deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in spermidine deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermidine deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyamine deacetylase HDAC10
NP_001403078.1
NP_001403079.1
NP_001403080.1
NP_001403081.1
NP_001403082.1
NP_001403083.1
NP_001403084.1
NP_001403085.1
NP_001403086.1
NP_001403087.1
NP_001403088.1
NP_001403089.1
NP_001403090.1
NP_001403091.1
NP_954668.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416149.1 → NP_001403078.1  polyamine deacetylase HDAC10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113069

  2. NM_001416150.1 → NP_001403079.1  polyamine deacetylase HDAC10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113069

  3. NM_001416151.1 → NP_001403080.1  polyamine deacetylase HDAC10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113069

  4. NM_001416152.1 → NP_001403081.1  polyamine deacetylase HDAC10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113069

  5. NM_001416153.1 → NP_001403082.1  polyamine deacetylase HDAC10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113069

  6. NM_001416154.1 → NP_001403083.1  polyamine deacetylase HDAC10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113069

  7. NM_001416155.1 → NP_001403084.1  polyamine deacetylase HDAC10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113069

  8. NM_001416156.1 → NP_001403085.1  polyamine deacetylase HDAC10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113069

  9. NM_001416157.1 → NP_001403086.1  polyamine deacetylase HDAC10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC113069

  10. NM_001416158.1 → NP_001403087.1  polyamine deacetylase HDAC10 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC113069

  11. NM_001416159.1 → NP_001403088.1  polyamine deacetylase HDAC10 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC113069

  12. NM_001416160.1 → NP_001403089.1  polyamine deacetylase HDAC10 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC113069

  13. NM_001416161.1 → NP_001403090.1  polyamine deacetylase HDAC10 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC113069

  14. NM_001416162.1 → NP_001403091.1  polyamine deacetylase HDAC10 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC113069

  15. NM_199198.3 → NP_954668.2  polyamine deacetylase HDAC10 isoform 1

    See identical proteins and their annotated locations for NP_954668.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC113069
    Consensus CDS
    CCDS27739.1
    UniProtKB/Swiss-Prot
    G3X9I8, Q6P3E7
    Related
    ENSMUSP00000080832.6, ENSMUST00000082197.12
    Conserved Domains (1) summary
    cl17011
    Location:18 → 354
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

  1. NR_028447.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235, BU706947
    Related
    ENSMUST00000129398.8

  2. NR_028448.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235
    Related
    ENSMUST00000128908.8

  3. NR_028449.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235, BU706947
    Related
    ENSMUST00000143465.8

  4. NR_183467.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113069

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89007506..89012903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3E7.2 GenPept UniProtKB/Swiss-Prot:Q6P3E7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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