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Hdac10 histone deacetylase 10 [ Mus musculus (house mouse) ]

Gene ID: 170787, updated on 12-May-2024

Summary

Official Symbol
Hdac10provided by MGI
Official Full Name
histone deacetylase 10provided by MGI
Primary source
MGI:MGI:2158340
See related
Ensembl:ENSMUSG00000062906 AllianceGenome:MGI:2158340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hd10
Summary
Predicted to enable histone deacetylase activity and histone deacetylase binding activity. Predicted to be involved in several processes, including homologous recombination; macromolecule deacylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within histone deacetylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 30.7), thymus adult (RPKM 25.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hdac10 in Genome Data Viewer
Location:
15 E3; 15 44.64 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89007506..89012903, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89123303..89128700, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylputrescine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylspermidine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in polyamine deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mismatch repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in spermidine deacetylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polyamine deacetylase HDAC10
NP_001403078.1
NP_001403079.1
NP_001403080.1
NP_001403081.1
NP_001403082.1
NP_001403083.1
NP_001403084.1
NP_001403085.1
NP_001403086.1
NP_001403087.1
NP_001403088.1
NP_001403089.1
NP_001403090.1
NP_001403091.1
NP_954668.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416149.1NP_001403078.1  polyamine deacetylase HDAC10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113069
  2. NM_001416150.1NP_001403079.1  polyamine deacetylase HDAC10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113069
  3. NM_001416151.1NP_001403080.1  polyamine deacetylase HDAC10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113069
  4. NM_001416152.1NP_001403081.1  polyamine deacetylase HDAC10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113069
  5. NM_001416153.1NP_001403082.1  polyamine deacetylase HDAC10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113069
  6. NM_001416154.1NP_001403083.1  polyamine deacetylase HDAC10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113069
  7. NM_001416155.1NP_001403084.1  polyamine deacetylase HDAC10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113069
  8. NM_001416156.1NP_001403085.1  polyamine deacetylase HDAC10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113069
  9. NM_001416157.1NP_001403086.1  polyamine deacetylase HDAC10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC113069
  10. NM_001416158.1NP_001403087.1  polyamine deacetylase HDAC10 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC113069
  11. NM_001416159.1NP_001403088.1  polyamine deacetylase HDAC10 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC113069
  12. NM_001416160.1NP_001403089.1  polyamine deacetylase HDAC10 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC113069
  13. NM_001416161.1NP_001403090.1  polyamine deacetylase HDAC10 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC113069
  14. NM_001416162.1NP_001403091.1  polyamine deacetylase HDAC10 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC113069
  15. NM_199198.3NP_954668.2  polyamine deacetylase HDAC10 isoform 1

    See identical proteins and their annotated locations for NP_954668.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC113069
    Consensus CDS
    CCDS27739.1
    UniProtKB/Swiss-Prot
    G3X9I8, Q6P3E7
    Related
    ENSMUSP00000080832.6, ENSMUST00000082197.12
    Conserved Domains (1) summary
    cl17011
    Location:18354
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

  1. NR_028447.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235, BU706947
    Related
    ENSMUST00000129398.8
  2. NR_028448.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235
    Related
    ENSMUST00000128908.8
  3. NR_028449.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113069, AI448228, AK040235, BU706947
    Related
    ENSMUST00000143465.8
  4. NR_183467.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113069

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89007506..89012903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)