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Tlr7 toll-like receptor 7 [ Mus musculus (house mouse) ]

Gene ID: 170743, updated on 31-Jan-2023

Summary

Official Symbol
Tlr7provided by MGI
Official Full Name
toll-like receptor 7provided by MGI
Primary source
MGI:MGI:2176882
See related
Ensembl:ENSMUSG00000044583 AllianceGenome:MGI:2176882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and toll-like receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tlr7 in Genome Data Viewer
Location:
X; X F5
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166086376..166113570, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167303380..167330574, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene thymosin, beta 4, X chromosome Neighboring gene toll-like receptor 8 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene predicted gene, 26368 Neighboring gene predicted gene 6744

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables siRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables single-stranded RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to cGMP ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 7 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
toll-like receptor 7
Names
Toll like receptor 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290755.1NP_001277684.1  toll-like receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_001277684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AJ812654, AK036549, AL731735, BY543663
    Consensus CDS
    CCDS72469.1
    UniProtKB/Swiss-Prot
    P58681, Q923I1
    UniProtKB/TrEMBL
    Q548J0
    Related
    ENSMUSP00000107787.2, ENSMUST00000112161.8
    Conserved Domains (5) summary
    PRK15370
    Location:32243
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:754838
    PCC; polycystin cation channel protein
    smart00255
    Location:8911036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:174786
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:497519
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001290756.1NP_001277685.1  toll-like receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_001277685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AJ812654, AK036549, AL731735, BY543663
    Consensus CDS
    CCDS72469.1
    UniProtKB/Swiss-Prot
    P58681, Q923I1
    UniProtKB/TrEMBL
    Q548J0
    Conserved Domains (5) summary
    PRK15370
    Location:32243
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:754838
    PCC; polycystin cation channel protein
    smart00255
    Location:8911036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:174786
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:497519
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001290757.1NP_001277686.1  toll-like receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_001277686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice site in the 5' region, and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AK036549, AL731735, BY543663
    Consensus CDS
    CCDS30531.1
    UniProtKB/Swiss-Prot
    P58681, Q923I1
    UniProtKB/TrEMBL
    Q548J0
    Related
    ENSMUSP00000107789.2, ENSMUST00000112164.2
    Conserved Domains (5) summary
    PRK15370
    Location:32243
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:754838
    PCC; polycystin cation channel protein
    smart00255
    Location:8911036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:174786
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:497519
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_001290758.1NP_001277687.1  toll-like receptor 7 isoform b

    See identical proteins and their annotated locations for NP_001277687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AJ812652, AK036549, AL731735, BY204351, BY543663
    UniProtKB/TrEMBL
    Q548J0, Q599W9
    Conserved Domains (5) summary
    PRK15370
    Location:35246
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:757841
    PCC; polycystin cation channel protein
    smart00255
    Location:8941039
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:177789
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:500522
    LRR_RI; leucine-rich repeat [structural motif]
  5. NM_133211.4NP_573474.1  toll-like receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_573474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AK036549, AL731735, BY543663
    Consensus CDS
    CCDS30531.1
    UniProtKB/Swiss-Prot
    P58681, Q923I1
    UniProtKB/TrEMBL
    Q548J0
    Related
    ENSMUSP00000061853.6, ENSMUST00000060719.12
    Conserved Domains (5) summary
    PRK15370
    Location:32243
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:754838
    PCC; polycystin cation channel protein
    smart00255
    Location:8911036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:174786
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:497519
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    166086376..166113570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528713.2XP_006528776.1  toll-like receptor 7 isoform X1

    See identical proteins and their annotated locations for XP_006528776.1

    Conserved Domains (5) summary
    PRK15370
    Location:35246
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:757841
    PCC; polycystin cation channel protein
    smart00255
    Location:8941039
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:177789
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:500522
    LRR_RI; leucine-rich repeat [structural motif]