Format

Send to:

Choose Destination

TLR7 toll like receptor 7 [ Homo sapiens (human) ]

Gene ID: 51284, updated on 23-Nov-2021

Summary

Official Symbol
TLR7provided by HGNC
Official Full Name
toll like receptor 7provided by HGNC
Primary source
HGNC:HGNC:15631
See related
Ensembl:ENSG00000196664 MIM:300365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD74; TLR7-like
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Broad expression in placenta (RPKM 3.3), appendix (RPKM 3.0) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TLR7 in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (12867072..12890361)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12885191..12908480)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 6 pseudogene 2 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 5588 Neighboring gene TLR8 antisense RNA 1 Neighboring gene toll like receptor 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency 74, COVID-19-related, X-linked
MedGen: C5435745 OMIM: 301051 GeneReviews: Not available
not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Combined activation of TLR7/8 and TLR9 by TLR7/8 and TLR9 agonists induces the highest titers of binding, neutralizing, and antibody-dependent cellular cytotoxicity-mediating antibodies against HIV-1 Env/gp140 PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of toll-like receptor 7 (TLR7) in peptide-treated PBMCs PubMed
reverse transcriptase gag-pol Gardiquimod, a Toll-like receptor-7 agonist, inhibits HIV-1 reverse transcriptase in HIV-1-infected macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables siRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in I-kappaB phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 7 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endolysosome membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
toll-like receptor 7
Names
toll-like receptor 7-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012569.1 RefSeqGene

    Range
    4990..28279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016562.4NP_057646.1  toll-like receptor 7 precursor

    See identical proteins and their annotated locations for NP_057646.1

    Status: REVIEWED

    Source sequence(s)
    AC005859, AF240467, BC033651
    Consensus CDS
    CCDS14151.1
    UniProtKB/Swiss-Prot
    Q9NYK1
    UniProtKB/TrEMBL
    B2R9N9
    Related
    ENSP00000370034.3, ENST00000380659.4
    Conserved Domains (6) summary
    TIGR00864
    Location:753837
    PCC; polycystin cation channel protein
    smart00255
    Location:890993
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:191711
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:488775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:496518
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:75139
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    12867072..12890361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_001066.3: Suppressed sequence

    Description
    NG_001066.3: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Support Center