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Rtn4ip1 reticulon 4 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 170728, updated on 30-Apr-2024

Summary

Official Symbol
Rtn4ip1provided by MGI
Official Full Name
reticulon 4 interacting protein 1provided by MGI
Primary source
MGI:MGI:2178759
See related
Ensembl:ENSMUSG00000019864 AllianceGenome:MGI:2178759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIMP; D10Ertd690e
Summary
Predicted to enable oxidoreductase activity and zinc ion binding activity. Involved in regulation of dendrite development. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 16.9), kidney adult (RPKM 9.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rtn4ip1 in Genome Data Viewer
Location:
10 B2; 10 23.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43777772..43823860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43901807..43947863)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933404K13 gene Neighboring gene STARR-positive B cell enhancer ABC_E1120 Neighboring gene STARR-seq mESC enhancer starr_26522 Neighboring gene STARR-seq mESC enhancer starr_26525 Neighboring gene STARR-seq mESC enhancer starr_26526 Neighboring gene STARR-seq mESC enhancer starr_26527 Neighboring gene glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E6838 Neighboring gene STARR-seq mESC enhancer starr_26529 Neighboring gene STARR-seq mESC enhancer starr_26530 Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene predicted gene, 40636 Neighboring gene STARR-seq mESC enhancer starr_26531 Neighboring gene STARR-seq mESC enhancer starr_26532 Neighboring gene STARR-seq mESC enhancer starr_26533 Neighboring gene preferentially expressed antigen in melanoma like 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
reticulon-4-interacting protein 1, mitochondrial
Names
NOGO-interacting mitochondrial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130892.5NP_570962.2  reticulon-4-interacting protein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_570962.2

    Status: VALIDATED

    Source sequence(s)
    AC153536, AC158637, AK050324
    Consensus CDS
    CCDS23823.1
    UniProtKB/Swiss-Prot
    Q8R1T0, Q924D0
    UniProtKB/TrEMBL
    A0A0R4J0S3
    Related
    ENSMUSP00000060940.6, ENSMUST00000054418.12
    Conserved Domains (2) summary
    cd08248
    Location:43394
    RTN4I1; Human Reticulon 4 Interacting Protein 1
    COG0604
    Location:43395
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RNA

  1. NR_152603.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153536, AC158637, AK050324, CF165433

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    43777772..43823860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155653.1XP_036011546.1  reticulon-4-interacting protein 1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8R1T0, Q924D0
    Conserved Domains (1) summary
    cd08248
    Location:43363
    RTN4I1; Human Reticulon 4 Interacting Protein 1