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RTN4IP1 reticulon 4 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 84816, updated on 4-Dec-2022

Summary

Official Symbol
RTN4IP1provided by HGNC
Official Full Name
reticulon 4 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:18647
See related
Ensembl:ENSG00000130347 MIM:610502; AllianceGenome:HGNC:18647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIMP; OPA10
Summary
This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in skin (RPKM 10.5), placenta (RPKM 7.8) and 24 other tissues See more
Orthologs
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Genomic context

See RTN4IP1 in Genome Data Viewer
Location:
6q21
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (106570771..106630491, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (107746918..107806978, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (107018646..107078366, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene uncharacterized LOC105377924 Neighboring gene uncharacterized LOC101927405 Neighboring gene Sharpr-MPRA regulatory region 441 Neighboring gene RNA, U6 small nuclear 527, pseudogene Neighboring gene ribosomal protein L21 pseudogene 65 Neighboring gene glutaminyl-tRNA amidotransferase subunit QRSL1 Neighboring gene long intergenic non-protein coding RNA 2526

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
reticulon-4-interacting protein 1, mitochondrial
Names
NOGO-interacting mitochondrial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047205.1 RefSeqGene

    Range
    6003..64730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318746.1NP_001305675.1  reticulon-4-interacting protein 1, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks aportion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK095207, AL390074, BC006399
    UniProtKB/Swiss-Prot
    Q8WWV3
    Conserved Domains (1) summary
    cd08248
    Location:1294
    RTN4I1; Human Reticulon 4 Interacting Protein 1
  2. NM_032730.5NP_116119.2  reticulon-4-interacting protein 1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_116119.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK095207, AL390074, BC006399
    Consensus CDS
    CCDS5056.1
    UniProtKB/Swiss-Prot
    Q8WWV3, Q9BRA4
    Related
    ENSP00000358059.3, ENST00000369063.8
    Conserved Domains (1) summary
    cd08248
    Location:43394
    RTN4I1; Human Reticulon 4 Interacting Protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    106570771..106630491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536192.3XP_011534494.1  reticulon-4-interacting protein 1, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd08248
    Location:12314
    RTN4I1; Human Reticulon 4 Interacting Protein 1
    smart00829
    Location:16313
    PKS_ER; Enoylreductase
  2. XM_017011376.3XP_016866865.1  reticulon-4-interacting protein 1, mitochondrial isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    107746918..107806978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)