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PWWP2B PWWP domain containing 2B [ Homo sapiens (human) ]

Gene ID: 170394, updated on 27-Nov-2024

Summary

Official Symbol
PWWP2Bprovided by HGNC
Official Full Name
PWWP domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:25150
See related
Ensembl:ENSG00000171813 AllianceGenome:HGNC:25150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PWWP2; pp8607; bA432J24.1
Summary
Enables NuRD complex binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 6.8), colon (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See PWWP2B in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132397200..132417859)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133344759..133365447)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134210704..134231363)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 32C Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134144980-134145514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4224 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134152941-134153095 Neighboring gene leucine rich repeat containing 27 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134166187-134167149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134203032-134203711 Neighboring gene uncharacterized LOC124902526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134208622-134209145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134209146-134209668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211239-134211761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211762-134212284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134214271-134215047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134218733-134219360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221245-134221872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221873-134222500 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134222501-134223127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134227291-134227958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134231824-134232727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134232728-134233632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134235443-134236346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134237164-134237690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134244072-134244572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134252266-134252930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134252931-134253594 Neighboring gene long intergenic non-protein coding RNA 3068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4225 Neighboring gene long intergenic non-protein coding RNA 2870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39621, FLJ46823

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NuRD complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
PWWP domain-containing protein 2B
Names
PWWP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098637.2NP_001092107.1  PWWP domain-containing protein 2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1,that results in a shorter protein (isoform 2) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AW166547, BC068574, BG260395, DB477789
    Consensus CDS
    CCDS44497.1
    UniProtKB/Swiss-Prot
    Q6NUJ5
    Related
    ENSP00000486501.1, ENST00000631148.2
  2. NM_138499.4NP_612508.3  PWWP domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_612508.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW166547, BC068574, DB477789
    Consensus CDS
    CCDS7667.2
    UniProtKB/Swiss-Prot
    A6NM90, B5MDQ1, H9KV61, Q5SZI0, Q6NUJ5, Q6ZQX5, Q96F43
    Related
    ENSP00000306324.5, ENST00000305233.6
    Conserved Domains (1) summary
    cd05835
    Location:488574
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132397200..132417859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539387.3XP_011537689.1  PWWP domain-containing protein 2B isoform X1

  2. XM_047424690.1XP_047280646.1  PWWP domain-containing protein 2B isoform X2

  3. XM_047424691.1XP_047280647.1  PWWP domain-containing protein 2B isoform X2

  4. XM_047424692.1XP_047280648.1  PWWP domain-containing protein 2B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133344759..133365447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364940.1XP_054220915.1  PWWP domain-containing protein 2B isoform X1

  2. XM_054364941.1XP_054220916.1  PWWP domain-containing protein 2B isoform X2

  3. XM_054364942.1XP_054220917.1  PWWP domain-containing protein 2B isoform X2

  4. XM_054364943.1XP_054220918.1  PWWP domain-containing protein 2B isoform X2