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PWWP2B PWWP domain containing 2B [ Homo sapiens (human) ]

Gene ID: 170394, updated on 22-Sep-2022

Summary

Official Symbol
PWWP2Bprovided by HGNC
Official Full Name
PWWP domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:25150
See related
Ensembl:ENSG00000171813 AllianceGenome:HGNC:25150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PWWP2; pp8607; bA432J24.1
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 6.8), colon (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See PWWP2B in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132397200..132417859)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133344759..133365447)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134210704..134231363)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 32C Neighboring gene leucine rich repeat containing 27 Neighboring gene uncharacterized LOC124902526 Neighboring gene long intergenic non-protein coding RNA 3068 Neighboring gene long intergenic non-protein coding RNA 2870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39621, FLJ46823

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NuRD complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of histone H3-K27 acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone H3-K9 acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PWWP domain-containing protein 2B
Names
PWWP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098637.2NP_001092107.1  PWWP domain-containing protein 2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1,that results in a shorter protein (isoform 2) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AW166547, BC068574, BG260395, DB477789
    Consensus CDS
    CCDS44497.1
    UniProtKB/Swiss-Prot
    Q6NUJ5
    Related
    ENSP00000486501.1, ENST00000631148.2
  2. NM_138499.4NP_612508.3  PWWP domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_612508.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW166547, BC068574, DB477789
    Consensus CDS
    CCDS7667.2
    UniProtKB/Swiss-Prot
    Q6NUJ5, Q96F43
    Related
    ENSP00000306324.5, ENST00000305233.6
    Conserved Domains (1) summary
    cd05835
    Location:488574
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132397200..132417859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539387.3XP_011537689.1  PWWP domain-containing protein 2B isoform X1

  2. XM_047424690.1XP_047280646.1  PWWP domain-containing protein 2B isoform X2

  3. XM_047424691.1XP_047280647.1  PWWP domain-containing protein 2B isoform X2

  4. XM_047424692.1XP_047280648.1  PWWP domain-containing protein 2B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133344759..133365447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)