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Pwwp2b PWWP domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 101631, updated on 21-Apr-2024

Summary

Official Symbol
Pwwp2bprovided by MGI
Official Full Name
PWWP domain containing 2Bprovided by MGI
Primary source
MGI:MGI:2142008
See related
Ensembl:ENSMUSG00000060260 AllianceGenome:MGI:2142008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pwwp2; D7Ertd517e; D930023J19Rik
Summary
Predicted to be located in nucleoplasm. Orthologous to human PWWP2B (PWWP domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 153.8), lung adult (RPKM 14.7) and 5 other tissues See more
Orthologs
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Genomic context

Location:
7 F4; 7 84.39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138828398..138847172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139248482..139267256)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 32C Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:146410713-146410866 Neighboring gene leucine rich repeat containing 27 Neighboring gene predicted gene, 32315 Neighboring gene predicted gene, 32486 Neighboring gene predicted gene, 51504 Neighboring gene predicted gene, 32571

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NuRD complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PWWP domain-containing protein 2B
Names
PWWP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033206.2NP_001028378.1  PWWP domain-containing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_001028378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1,that results in a shorter protein (isoform 2) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AK158245, BC116669
    Consensus CDS
    CCDS40169.1
    UniProtKB/TrEMBL
    Q14AS8, Q3TYY8
    Related
    ENSMUSP00000091529.4, ENSMUST00000093993.5
    Conserved Domains (1) summary
    pfam10243
    Location:189344
    MIP-T3; Microtubule-binding protein MIP-T3
  2. NM_001098636.1NP_001092106.1  PWWP domain-containing protein 2B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158245, AK213732, BC116669
    Consensus CDS
    CCDS52427.1
    UniProtKB/Swiss-Prot
    E9Q9M8
    UniProtKB/TrEMBL
    Q14AS8
    Related
    ENSMUSP00000130888.2, ENSMUST00000172136.9
    Conserved Domains (1) summary
    cd05835
    Location:498583
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138828398..138847172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030241947.1XP_030097807.1  PWWP domain-containing protein 2B isoform X1

    UniProtKB/TrEMBL
    Q14AS8
    Conserved Domains (1) summary
    cd05835
    Location:421506
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...