Anxa1 annexin A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa1provided by MGI
Official Full Name: annexin A1provided by MGI
Primary source: MGI:MGI:96819
See related: Ensembl:ENSMUSG00000024659 AllianceGenome:MGI:96819
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lpc1; Anx-1; Lpc-1; Anx-A1; C430014K04Rik
Summary: Predicted to enable several functions, including calcium-dependent phospholipid binding activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Predicted to contribute to single-stranded RNA binding activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; neutrophil homeostasis; and positive regulation of neutrophil apoptotic process. Acts upstream of or within several processes, including arachidonic acid secretion; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; lateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; skeleton; and skin. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 55.7), liver E18 (RPKM 42.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 13.83 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (20350798..20368035, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (20373434..20390671, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets.
Title: Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets.
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro.
Title: Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro.
Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis.
Title: Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis.
Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.
Title: Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.
Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1.
Title: Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1.
Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection.
Title: Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection.
Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.
Title: Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.
Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis.
Title: Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis.
Annexin-A1 deficiency attenuates stress-induced tumor growth via fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axis.
Title: Annexin-A1 deficiency attenuates stress-induced tumor growth via fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axis.
Annexin A1 Promotes Reparative Angiogenesis and Ameliorates Neuronal Injury in Ischemic Retinopathy.
Title: Annexin A1 Promotes Reparative Angiogenesis and Ameliorates Neuronal Injury in Ischemic Retinopathy.

Submit: New GeneRIF Correction See all GeneRIFs (133)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Anxa1 (e-PCR), detects polymorphism
- UniSTS:498460

Anxa1 (e-PCR), detects polymorphism
- UniSTS:143790

Anxa1 (e-PCR), detects polymorphism
- UniSTS:143791

RH129631 (e-PCR)
- UniSTS:212928

ANXA1 (e-PCR)
- UniSTS:509949

Homology

Homologs of the Anxa1 gene: The Anxa1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 463 organisms have orthologs with human gene Anxa1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA/DNA annealing activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phospholipase A2 inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton reorganization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in alpha-beta T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within arachidonic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in estrous cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in gliogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in granulocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in localization	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration involved in skeletal muscle regeneration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in myoblast migration involved in skeletal muscle regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T-helper 2 cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil clearance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neutrophil clearance	ISO Inferred from Sequence Orthology more info
involved_in neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in prolactin secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in prolactin secretion	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of interleukin-1 production	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of interleukin-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to interleukin-1	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sequestering of metal ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mast cell granule	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: annexin A1

Names: annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; p35; phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.