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ANXA1 annexin A1 [ Homo sapiens (human) ]

Gene ID: 301, updated on 18-Jun-2019

Summary

Official Symbol
ANXA1provided by HGNC
Official Full Name
annexin A1provided by HGNC
Primary source
HGNC:HGNC:533
See related
Ensembl:ENSG00000135046 MIM:151690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANX1; LPC1
Summary
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Expression
Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues See more
Orthologs

Genomic context

See ANXA1 in Genome Data Viewer
Location:
9q21.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (73151865..73170393)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75766721..75785309)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 1 subfamily D member 1, pseudogene Neighboring gene uncharacterized LOC105376081 Neighboring gene uncharacterized LOC105376082 Neighboring gene uncharacterized LOC101927281

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
    Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemThe formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF)....
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18726

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA/DNA annealing activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding involved in cell-cell adhesion HDA PubMed 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipase A2 inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
alpha-beta T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endocrine pancreas development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT estrous cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gliogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
granulocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
granulocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
hepatocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
myoblast migration involved in skeletal muscle regeneration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T-helper 2 cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-8 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T-helper 1 cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T-helper 1 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-2 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
prolactin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostate gland development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-1 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of interleukin-1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to estradiol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction HDA PubMed 
collagen-containing extracellular matrix HDA PubMed 
cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
annexin A1
Names
annexin I (lipocortin I)
annexin-1
calpactin II
calpactin-2
chromobindin-9
epididymis secretory sperm binding protein
phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000700.3NP_000691.1  annexin A1

    See identical proteins and their annotated locations for NP_000691.1

    Status: REVIEWED

    Source sequence(s)
    AA039737, AL359997, X05908
    Consensus CDS
    CCDS6645.1
    UniProtKB/Swiss-Prot
    P04083
    UniProtKB/TrEMBL
    Q5TZZ9
    Related
    ENSP00000257497.6, ENST00000257497.11
    Conserved Domains (1) summary
    pfam00191
    Location:118183
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    73151865..73170393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014657.1XP_016870146.1  annexin A1 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:129194
    Annexin; Annexin
  2. XM_011518609.1XP_011516911.1  annexin A1 isoform X2

    See identical proteins and their annotated locations for XP_011516911.1

    UniProtKB/Swiss-Prot
    P04083
    UniProtKB/TrEMBL
    Q5TZZ9
    Related
    ENSP00000366109.1, ENST00000376911.1
    Conserved Domains (1) summary
    pfam00191
    Location:118183
    Annexin; Annexin
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