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Cog1 component of oligomeric golgi complex 1 [ Mus musculus (house mouse) ]

Gene ID: 16834, updated on 30-Apr-2024

Summary

Official Symbol
Cog1provided by MGI
Official Full Name
component of oligomeric golgi complex 1provided by MGI
Primary source
MGI:MGI:1333873
See related
Ensembl:ENSMUSG00000018661 AllianceGenome:MGI:1333873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldlb; mKIAA1381; 6030445I15
Summary
Predicted to be involved in intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex and cerebral cortex marginal layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 24.9), testis adult (RPKM 20.1) and 28 other tissues See more
Orthologs
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Genomic context

See Cog1 in Genome Data Viewer
Location:
11 E2; 11 79.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113540004..113560157)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113649178..113669331)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene somatostatin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene STARR-positive B cell enhancer ABC_E8469 Neighboring gene CDC42 effector protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1381

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 1
Names
COG complex subunit 1
low density lipoprotein B
low density lipoprotein receptor defect B-complementing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013581.3NP_038609.3  conserved oligomeric Golgi complex subunit 1

    See identical proteins and their annotated locations for NP_038609.3

    Status: VALIDATED

    Source sequence(s)
    BC063056, BY721599
    Consensus CDS
    CCDS25599.1
    UniProtKB/Swiss-Prot
    Q6P567, Q9Z160
    UniProtKB/TrEMBL
    Q3TR89, Q3TWY6
    Related
    ENSMUSP00000018805.9, ENSMUST00000018805.15
    Conserved Domains (1) summary
    pfam08700
    Location:1791
    Vps51; Vps51/Vps67

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    113540004..113560157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532343.4XP_006532406.1  conserved oligomeric Golgi complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    Q5DTY3
    Conserved Domains (1) summary
    pfam08700
    Location:39114
    Vps51; Vps51/Vps67
  2. XM_006532346.2XP_006532409.1  conserved oligomeric Golgi complex subunit 1 isoform X3

    UniProtKB/TrEMBL
    Q3U7X8
  3. XM_006532344.2XP_006532407.1  conserved oligomeric Golgi complex subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_006532407.1

    UniProtKB/TrEMBL
    Q5DTY3
    Conserved Domains (1) summary
    pfam08700
    Location:39114
    Vps51; Vps51/Vps67
  4. XM_006532345.2XP_006532408.1  conserved oligomeric Golgi complex subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_006532408.1

    UniProtKB/TrEMBL
    Q5DTY3
    Conserved Domains (1) summary
    pfam08700
    Location:39114
    Vps51; Vps51/Vps67

RNA

  1. XR_388357.2 RNA Sequence

  2. XR_388356.2 RNA Sequence