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Lama1 laminin, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 16772, updated on 13-Feb-2024

Summary

Official Symbol
Lama1provided by MGI
Official Full Name
laminin, alpha 1provided by MGI
Primary source
MGI:MGI:99892
See related
Ensembl:ENSMUSG00000032796 AllianceGenome:MGI:99892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lama
Summary
Enables glycosphingolipid binding activity. An extracellular matrix structural constituent. Involved in protein phosphorylation. Acts upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Located in basement membrane and cell-cell junction. Part of laminin-1 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 19.3), placenta adult (RPKM 10.0) and 8 other tissues See more
Orthologs
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Genomic context

See Lama1 in Genome Data Viewer
Location:
17 E1.1; 17 38.8 cM
Exon count:
65
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68004129..68129640)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (67697127..67822645)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43094 Neighboring gene predicted gene, 36201 Neighboring gene STARR-seq mESC enhancer starr_43095 Neighboring gene STARR-seq mESC enhancer starr_43096 Neighboring gene predicted gene, 52321 Neighboring gene leucine rich repeat containing 30 Neighboring gene Rho GTPase activating protein 28 Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular matrix structural constituent IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables glycosphingolipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in blood vessel morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in camera-type eye development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of basement membrane organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in basement membrane TAS
Traceable Author Statement
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of laminin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of laminin-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of laminin-1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of laminin-3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein complex involved in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
laminin subunit alpha-1
Names
S-LAM alpha
S-laminin subunit alpha
laminin A chain
laminin-1 subunit alpha
laminin-3 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008480.2NP_032506.2  laminin subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_032506.2

    Status: VALIDATED

    Source sequence(s)
    AC154823, AK051116, CA535780, CN461817, CN535171, J04064
    Consensus CDS
    CCDS37681.1
    UniProtKB/Swiss-Prot
    F8VQ40, P19137
    Related
    ENSMUSP00000043957.8, ENSMUST00000035471.9
    Conserved Domains (10) summary
    smart00136
    Location:25275
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:9581002
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:15161553
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:29003053
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:909955
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:27512880
    Laminin_G_1; Laminin G domain
    pfam06009
    Location:20182152
    Laminin_II; Laminin Domain II
    pfam00052
    Location:575714
    Laminin_B; Laminin B (Domain IV)
    pfam06008
    Location:15821837
    Laminin_I; Laminin Domain I
    cl25642
    Location:18272064
    DUF390; Protein of unknown function (DUF390)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    68004129..68129640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523718.5XP_006523781.1  laminin subunit alpha-1 isoform X3

    Conserved Domains (5) summary
    smart00136
    Location:25275
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:9581002
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:15161553
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:575714
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:909955
    Laminin_EGF; Laminin EGF domain
  2. XM_006523717.5XP_006523780.1  laminin subunit alpha-1 isoform X1

    Conserved Domains (10) summary
    smart00136
    Location:25275
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:9581002
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    COG4372
    Location:17372044
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00055
    Location:15161553
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:23142470
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:15821837
    Laminin_I; Laminin Domain I
    pfam00054
    Location:27512880
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:575714
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:909955
    Laminin_EGF; Laminin EGF domain
    pfam06009
    Location:20182152
    Laminin_II; Laminin Domain II
  3. XM_030249517.2XP_030105377.1  laminin subunit alpha-1 isoform X2

    Conserved Domains (10) summary
    smart00180
    Location:713757
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    COG4372
    Location:14921799
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00055
    Location:12711308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:26552808
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:13371592
    Laminin_I; Laminin Domain I
    pfam00054
    Location:25062635
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:330469
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:664710
    Laminin_EGF; Laminin EGF domain
    pfam06009
    Location:17731907
    Laminin_II; Laminin Domain II
    cl02806
    Location:730
    Laminin_N; Laminin N-terminal (Domain VI)
  4. XM_030249518.2XP_030105378.1  laminin subunit alpha-1 isoform X2

    Conserved Domains (10) summary
    smart00180
    Location:713757
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    COG4372
    Location:14921799
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00055
    Location:12711308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:26552808
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:13371592
    Laminin_I; Laminin Domain I
    pfam00054
    Location:25062635
    Laminin_G_1; Laminin G domain
    pfam00052
    Location:330469
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:664710
    Laminin_EGF; Laminin EGF domain
    pfam06009
    Location:17731907
    Laminin_II; Laminin Domain II
    cl02806
    Location:730
    Laminin_N; Laminin N-terminal (Domain VI)