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TENT2 terminal nucleotidyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 167153, updated on 22-Mar-2020

Summary

Official Symbol
TENT2provided by HGNC
Official Full Name
terminal nucleotidyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:26776
See related
Ensembl:ENSG00000164329 MIM:614121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APD4; GLD2; TUT2; PAPD4
Expression
Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See TENT2 in Genome Data Viewer
Location:
5q14.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (79612417..79688246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78908243..78982471)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 32 Neighboring gene uncharacterized LOC105379047 Neighboring gene cardiomyopathy associated 5 Neighboring gene uncharacterized LOC102724557

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel locus FER is associated with serum HMW adiponectin levels.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38499

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
RNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
dark adaptation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of miRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nuclear RNA-directed RNA polymerase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
poly(A) RNA polymerase GLD2
Names
PAP associated domain containing 4
PAP-associated domain-containing protein 4
TUTase 2
hGLD-2
poly(A) RNA polymerase D4, non-canonical
terminal uridylyltransferase 2
NP_001107865.1
NP_001107866.1
NP_001284673.1
NP_001284674.1
NP_001336477.1
NP_001336478.1
NP_001336479.1
NP_001336480.1
NP_001336481.1
NP_001336482.1
NP_001336483.1
NP_776158.2
XP_011541522.1
XP_011541523.1
XP_011541524.1
XP_011541525.1
XP_011541526.1
XP_011541527.1
XP_011541529.1
XP_011541531.1
XP_011541532.1
XP_011541533.1
XP_011541534.1
XP_011541535.1
XP_016864640.1
XP_016864641.1
XP_016864644.1
XP_016864645.1
XP_016864646.1
XP_016864648.1
XP_016864649.1
XP_016864650.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114393.3NP_001107865.1  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_001107865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 10, and 11 encode the same protein (isoform 1).
    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  2. NM_001114394.2NP_001107866.1  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_001107866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, 10, and 11 encode the same protein (isoform 1).
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7
    Related
    ENSP00000397563.1, ENST00000453514.5
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  3. NM_001297744.3NP_001284673.1  poly(A) RNA polymerase GLD2 isoform 2

    See identical proteins and their annotated locations for NP_001284673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region. The resulting isoform (2) has the same N- and C-termini, but is shorter than isoform 1. Variants 4 and 12 encode the same protein (isoform 2).
    Source sequence(s)
    AC008482, AW302247, BC047581, DB302918
    Consensus CDS
    CCDS75266.1
    UniProtKB/Swiss-Prot
    Q6PIY7
    Related
    ENSP00000393412.2, ENST00000423041.6
    Conserved Domains (1) summary
    cl27230
    Location:154464
    PAP_assoc; Cid1 family poly A polymerase
  4. NM_001297745.3NP_001284674.1  poly(A) RNA polymerase GLD2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC008482, AL833136, AW302247, BC047581, DB302918
    Consensus CDS
    CCDS75265.1
    UniProtKB/TrEMBL
    D6RAF2
    Related
    ENSP00000421966.1, ENST00000504233.5
    Conserved Domains (2) summary
    cd05402
    Location:176298
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:343397
    PAP_assoc; Cid1 family poly A polymerase
  5. NM_001349548.2NP_001336477.1  poly(A) RNA polymerase GLD2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, one of which results in the use of an alternate start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
    Conserved Domains (1) summary
    cl27230
    Location:4245
    PAP_assoc; Cid1 family poly A polymerase
  6. NM_001349549.2NP_001336478.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (5) has the same N- and C-termini, but is longer than isoform 1. Variants 7 and 8 encode the same protein (isoform 5).
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  7. NM_001349550.2NP_001336479.1  poly(A) RNA polymerase GLD2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (5) has the same N- and C-termini, but is longer than isoform 1. Variants 7 and 8 encode the same protein (isoform 5).
    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  8. NM_001349551.2NP_001336480.1  poly(A) RNA polymerase GLD2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (6) has the same N- and C-termini, but is longer than isoform 1.
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
    Conserved Domains (1) summary
    cl27230
    Location:154489
    PAP_assoc; Cid1 family poly A polymerase
  9. NM_001349552.2NP_001336481.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 10, and 11 encode the same protein (isoform 1).
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  10. NM_001349553.2NP_001336482.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 10, and 11 encode the same protein (isoform 1).
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  11. NM_001349554.2NP_001336483.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region. The resulting isoform (2) has the same N- and C-termini, but is shorter than isoform 1. Variants 4 and 12 encode the same protein (isoform 2).
    Source sequence(s)
    AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS75266.1
    Conserved Domains (1) summary
    cl27230
    Location:154464
    PAP_assoc; Cid1 family poly A polymerase
  12. NM_173797.5NP_776158.2  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_776158.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 10, and 11 encode the same protein (isoform 1).
    Source sequence(s)
    AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
    Consensus CDS
    CCDS4048.1
    UniProtKB/Swiss-Prot
    Q6PIY7
    Related
    ENSP00000296783.3, ENST00000296783.7
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    79612417..79688246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009156.2XP_016864645.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  2. XM_011543227.2XP_011541529.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541529.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  3. XM_011543224.2XP_011541526.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541526.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  4. XM_011543229.3XP_011541531.1  poly(A) RNA polymerase GLD2 isoform X5

    Conserved Domains (2) summary
    cd05402
    Location:176323
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:368422
    PAP_assoc; Cid1 family poly A polymerase
  5. XM_011543221.3XP_011541523.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541523.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  6. XM_017009161.2XP_016864650.1  poly(A) RNA polymerase GLD2 isoform X10

  7. XM_011543222.3XP_011541524.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541524.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  8. XM_017009155.2XP_016864644.1  poly(A) RNA polymerase GLD2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PIY7
    Related
    ENSP00000396861.2, ENST00000428308.6
    Conserved Domains (1) summary
    cl27230
    Location:154468
    PAP_assoc; Cid1 family poly A polymerase
  9. XM_017009159.2XP_016864648.1  poly(A) RNA polymerase GLD2 isoform X4

    UniProtKB/Swiss-Prot
    Q6PIY7
    Conserved Domains (1) summary
    cl27230
    Location:154464
    PAP_assoc; Cid1 family poly A polymerase
  10. XM_017009151.2XP_016864640.1  poly(A) RNA polymerase GLD2 isoform X1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  11. XM_011543220.3XP_011541522.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541522.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  12. XM_017009152.2XP_016864641.1  poly(A) RNA polymerase GLD2 isoform X2

    Conserved Domains (1) summary
    cl27230
    Location:154489
    PAP_assoc; Cid1 family poly A polymerase
  13. XM_017009157.2XP_016864646.1  poly(A) RNA polymerase GLD2 isoform X4

    UniProtKB/Swiss-Prot
    Q6PIY7
    Conserved Domains (1) summary
    cl27230
    Location:154464
    PAP_assoc; Cid1 family poly A polymerase
  14. XM_011543230.3XP_011541532.1  poly(A) RNA polymerase GLD2 isoform X6

    Conserved Domains (1) summary
    cd05402
    Location:176298
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
  15. XM_011543231.3XP_011541533.1  poly(A) RNA polymerase GLD2 isoform X7

    Conserved Domains (1) summary
    cd05402
    Location:176273
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
  16. XM_011543223.2XP_011541525.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541525.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  17. XM_011543225.2XP_011541527.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_011541527.1

    Conserved Domains (1) summary
    cl27230
    Location:154493
    PAP_assoc; Cid1 family poly A polymerase
  18. XM_017009160.1XP_016864649.1  poly(A) RNA polymerase GLD2 isoform X4

    UniProtKB/Swiss-Prot
    Q6PIY7
    Conserved Domains (1) summary
    cl27230
    Location:154464
    PAP_assoc; Cid1 family poly A polymerase
  19. XM_011543232.2XP_011541534.1  poly(A) RNA polymerase GLD2 isoform X8

    Conserved Domains (2) summary
    cd05402
    Location:35104
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:192246
    PAP_assoc; Cid1 family poly A polymerase
  20. XM_011543233.2XP_011541535.1  poly(A) RNA polymerase GLD2 isoform X9

    Conserved Domains (2) summary
    cd05402
    Location:31100
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:188242
    PAP_assoc; Cid1 family poly A polymerase

RNA

  1. XR_948240.3 RNA Sequence

  2. XR_001742029.2 RNA Sequence

  3. XR_001742028.2 RNA Sequence

  4. XR_001742030.1 RNA Sequence

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