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RASSF6 Ras association domain family member 6 [ Homo sapiens (human) ]

Gene ID: 166824, updated on 23-Nov-2021

Summary

Official Symbol
RASSF6provided by HGNC
Official Full Name
Ras association domain family member 6provided by HGNC
Primary source
HGNC:HGNC:20796
See related
Ensembl:ENSG00000169435 MIM:612620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in stomach (RPKM 5.6), colon (RPKM 3.3) and 15 other tissues See more
Orthologs
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Genomic context

See RASSF6 in Genome Data Viewer
Location:
4q13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (73571550..73620631, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74437267..74486348, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2499 Neighboring gene Sharpr-MPRA regulatory region 8651 Neighboring gene uncharacterized LOC107986287 Neighboring gene uncharacterized LOC105377272 Neighboring gene Sharpr-MPRA regulatory region 6280 Neighboring gene C-X-C motif chemokine ligand 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686K23225

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras association domain-containing protein 6
Names
Ras association (RalGDS/AF-6) domain family 6
Ras association (RalGDS/AF-6) domain family member 6
putative RAS binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270391.2NP_001257320.1  ras association domain-containing protein 6 isoform c

    See identical proteins and their annotated locations for NP_001257320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. It encodes isoform c which is shorter than isoform a.
    Source sequence(s)
    AC074250
    Consensus CDS
    CCDS58904.1
    UniProtKB/Swiss-Prot
    Q6ZTQ3
    Related
    ENSP00000379123.2, ENST00000395777.6
    Conserved Domains (2) summary
    pfam16517
    Location:253291
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:189239
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. NM_001270392.1NP_001257321.1  ras association domain-containing protein 6 isoform d

    See identical proteins and their annotated locations for NP_001257321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame exons in the 5' coding region compared to variant 1. It encodes isoform d which is shorter than isoform a.
    Source sequence(s)
    AC074250, AI579909, AK126346, AW070877, AW407403, AY217665, BM923326, BX424428, BX957171
    Consensus CDS
    CCDS58905.1
    UniProtKB/Swiss-Prot
    Q6ZTQ3
    Related
    ENSP00000335582.5, ENST00000335049.5
    Conserved Domains (2) summary
    cd17223
    Location:175261
    RA_RASSF6; Ras-associating (RA) domain found in Ras-association domain-containing protein 6 (RASSF6)
    pfam16517
    Location:275313
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
  3. NM_177532.5NP_803876.1  ras association domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_803876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes isoform a.
    Source sequence(s)
    AC074250
    Consensus CDS
    CCDS3559.1
    UniProtKB/Swiss-Prot
    Q6ZTQ3
    Related
    ENSP00000303877.5, ENST00000307439.10
    Conserved Domains (2) summary
    pfam16517
    Location:287325
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:187273
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. NM_201431.2NP_958834.1  ras association domain-containing protein 6 isoform b

    See identical proteins and their annotated locations for NP_958834.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' coding region and uses an upstream start codon compared to variant 1. It encodes isoform b which has a longer N-terminus compared to isoform a.
    Source sequence(s)
    AC074250, AI579909, AK126346, AW070877, AW407403, BM923326, BX424428, BX957171
    Consensus CDS
    CCDS3558.1
    UniProtKB/Swiss-Prot
    Q6ZTQ3
    Related
    ENSP00000340578.3, ENST00000342081.7
    Conserved Domains (2) summary
    pfam16517
    Location:319357
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:219305
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    73571550..73620631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453917.1XP_024309685.1  ras association domain-containing protein 6 isoform X4

    Conserved Domains (2) summary
    pfam16517
    Location:229267
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:129215
    UBQ; Ubiquitin-like proteins
  2. XM_011531688.1XP_011529990.1  ras association domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011529990.1

    UniProtKB/Swiss-Prot
    Q6ZTQ3
    Conserved Domains (2) summary
    pfam16517
    Location:287325
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:187273
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. XM_011531690.2XP_011529992.1  ras association domain-containing protein 6 isoform X4

    See identical proteins and their annotated locations for XP_011529992.1

    Conserved Domains (2) summary
    pfam16517
    Location:229267
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:129215
    UBQ; Ubiquitin-like proteins
  4. XM_011531689.3XP_011529991.1  ras association domain-containing protein 6 isoform X3

    Conserved Domains (2) summary
    pfam16517
    Location:285323
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:221271
    UBQ; Ubiquitin-like proteins
  5. XM_017007837.2XP_016863326.1  ras association domain-containing protein 6 isoform X5

  6. XM_011531687.2XP_011529989.1  ras association domain-containing protein 6 isoform X1

    Conserved Domains (2) summary
    pfam16517
    Location:319343
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:219305
    UBQ; Ubiquitin-like proteins
  7. XM_017007838.1XP_016863327.1  ras association domain-containing protein 6 isoform X6

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