Format

Send to:

Choose Destination

Klk1b24 kallikrein 1-related peptidase b24 [ Mus musculus (house mouse) ]

Gene ID: 16617, updated on 12-Mar-2017
Official Symbol
Klk1b24provided by MGI
Official Full Name
kallikrein 1-related peptidase b24provided by MGI
Primary source
MGI:MGI:892021
See related
Ensembl:ENSMUSG00000063713 Vega:OTTMUSG00000027256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klk24; mGk-24
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
Location:
7 B3; 7 28.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44188234..44192455)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51443633..51447822)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b22 Neighboring gene kallikrein 1-related peptidase b16 Neighboring gene kallikrein 1-related peptidase b23, pseudogene Neighboring gene kallikrein 1-related peptidase b3 Neighboring gene kallikrein 1-related pepidase b4

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
kallikrein 1-related peptidase b24
Names
glandular kallikrein K24
tissue kallikrein 24
NP_034773.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010643.2NP_034773.1  kallikrein 1-related peptidase b24 preproprotein

    See identical proteins and their annotated locations for NP_034773.1

    Status: REVIEWED

    Source sequence(s)
    AB039277, BC146019
    Consensus CDS
    CCDS21198.1
    UniProtKB/Swiss-Prot
    Q61754
    Related
    ENSMUSP00000073392, OTTMUSP00000033904, ENSMUST00000073713, OTTMUST00000067395
    Conserved Domains (2) summary
    smart00020
    Location:24255
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    44188234..44192455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540674.3XP_006540737.1  kallikrein 1-related peptidase b24 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:24252
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25255
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Support Center