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Kif4 kinesin family member 4 [ Mus musculus (house mouse) ]

Gene ID: 16571, updated on 18-Apr-2024

Summary

Official Symbol
Kif4provided by MGI
Official Full Name
kinesin family member 4provided by MGI
Primary source
MGI:MGI:108389
See related
Ensembl:ENSMUSG00000034311 AllianceGenome:MGI:108389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kns4; D330050K22Rik
Summary
Predicted to enable several functions, including ATP binding activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in mitotic spindle organization. Predicted to be located in midbody and nucleoplasm. Is expressed in several structures, including alimentary system; brain; extraembryonic component; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 10.5), liver E14 (RPKM 7.2) and 9 other tissues See more
Orthologs
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Genomic context

Location:
X C3; X 43.72 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99669693..99770878)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100626065..100727271)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47635 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 Neighboring gene arrestin 3, retinal Neighboring gene PDZ domain containing 11 Neighboring gene predicted gene, 52438 Neighboring gene STARR-seq mESC enhancer starr_47636 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_47637 Neighboring gene predicted gene 14866 Neighboring gene predicted gene 14902

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chromosome-associated kinesin KIF4
Names
N-5 kinesin
chromokinesin
kinesin heavy chain member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008446.3NP_032472.2  chromosome-associated kinesin KIF4

    See identical proteins and their annotated locations for NP_032472.2

    Status: VALIDATED

    Source sequence(s)
    BX005480, BX276129
    Consensus CDS
    CCDS30305.1
    UniProtKB/Swiss-Prot
    P33174, Q80YP3
    Related
    ENSMUSP00000048383.4, ENSMUST00000048962.4
    Conserved Domains (4) summary
    smart00129
    Location:9344
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:407995
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:8338
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:10701120
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99669693..99770878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527855.5XP_006527918.1  chromosome-associated kinesin KIF4 isoform X1

    Conserved Domains (3) summary
    COG0419
    Location:407987
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:8338
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:10451087
    Pre-SET; Pre-SET motif
  2. XM_011247528.4XP_011245830.1  chromosome-associated kinesin KIF4 isoform X2

    See identical proteins and their annotated locations for XP_011245830.1

    Conserved Domains (3) summary
    COG0419
    Location:18606
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02169
    Location:173459
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05033
    Location:689731
    Pre-SET; Pre-SET motif
  3. XM_017318397.3XP_017173886.1  chromosome-associated kinesin KIF4 isoform X3

    Conserved Domains (2) summary
    COG0419
    Location:44518
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam05033
    Location:601643
    Pre-SET; Pre-SET motif