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KIF4A kinesin family member 4A [ Homo sapiens (human) ]

Gene ID: 24137, updated on 12-Sep-2021

Summary

Official Symbol
KIF4Aprovided by HGNC
Official Full Name
kinesin family member 4Aprovided by HGNC
Primary source
HGNC:HGNC:13339
See related
Ensembl:ENSG00000090889 MIM:300521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF4; KIF4G1; MRX100; XLID100
Summary
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Expression
Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues See more
Orthologs
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Genomic context

See KIF4A in Genome Data Viewer
Location:
Xq13.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70290104..70420886)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69509954..69640736)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene arrestin 3 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11 Neighboring gene TRAPPC2L pseudogene 1 Neighboring gene RNY4 pseudogene 23 Neighboring gene uncharacterized LOC105373244 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene discs large MAGUK scaffold protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed
matrix gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Binding of HIV-1 Matrix to KIF-4 may play a role in HIV-1 Gag polyprotein relocalize from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Matrix is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12530, FLJ12655, FLJ14204, FLJ20631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organelle organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in spindle microtubule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
chromosome-associated kinesin KIF4A
Names
chromokinesin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016799.1 RefSeqGene

    Range
    5001..135896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012310.5NP_036442.3  chromosome-associated kinesin KIF4A

    See identical proteins and their annotated locations for NP_036442.3

    Status: REVIEWED

    Source sequence(s)
    AL139398, AL357752
    Consensus CDS
    CCDS14401.1
    UniProtKB/Swiss-Prot
    O95239
    UniProtKB/TrEMBL
    Q59HG1
    Related
    ENSP00000363524.3, ENST00000374403.4
    Conserved Domains (4) summary
    COG1196
    Location:558918
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:375714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01372
    Location:8337
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:10781120
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70290104..70420886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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