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Kif3a kinesin family member 3A [ Mus musculus (house mouse) ]

Gene ID: 16568, updated on 18-Apr-2024

Summary

Official Symbol
Kif3aprovided by MGI
Official Full Name
kinesin family member 3Aprovided by MGI
Primary source
MGI:MGI:107689
See related
Ensembl:ENSMUSG00000018395 AllianceGenome:MGI:107689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif3; Kifl; Kns3
Summary
Enables intraciliary transport particle B binding activity and microtubule binding activity. Involved in centriole-centriole cohesion and microtubule anchoring at centrosome. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and plasma membrane bounded cell projection organization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of kinesin II complex. Is expressed in several structures, including gonad; liver; neural tube; node; and spleen. Used to study dysostosis and polycystic kidney disease. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 37.4), CNS E14 (RPKM 26.5) and 14 other tissues See more
Orthologs
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Genomic context

Location:
11 B1.3; 11 31.97 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53456531..53495075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53565701..53604248)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:53330337-53330520 Neighboring gene STARR-seq mESC enhancer starr_29486 Neighboring gene septin 8 Neighboring gene cyclin-like Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene STARR-seq mESC enhancer starr_29488 Neighboring gene STARR-seq mESC enhancer starr_29489 Neighboring gene origin of replication in Il13 Neighboring gene interleukin 4 Neighboring gene interleukin 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 111-11-71, 111-11-86

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intraciliary transport particle B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in alpha-tubulin acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anterograde dendritic transport EXP
Inferred from Experiment
more info
PubMed 
involved_in anterograde dendritic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anterograde dendritic transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in anterograde dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde dendritic transport of neurotransmitter receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anterograde dendritic transport of neurotransmitter receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cilium movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axo-dendritic protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of establishment or maintenance of cell polarity regulating cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin II complex ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF3A
Names
N-4 kinesin
kinesin-II subunit
microtubule plus end-directed kinesin motor 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290805.1NP_001277734.1  kinesin-like protein KIF3A isoform 2

    See identical proteins and their annotated locations for NP_001277734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK053412, AK084748, AK147078, AK149180, AV356644, BB752635, BC052707, CJ157264
    Consensus CDS
    CCDS70185.1
    UniProtKB/TrEMBL
    Q3UI47
    Related
    ENSMUSP00000056197.9, ENSMUST00000057330.15
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20345
    Kinesin; Kinesin motor domain
  2. NM_001290806.1NP_001277735.1  kinesin-like protein KIF3A isoform 3

    See identical proteins and their annotated locations for NP_001277735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK053412, AK084748, AK149180, AK169425, AV356644, BB752635, BC052707, CJ157264
    Consensus CDS
    CCDS78947.1
    UniProtKB/TrEMBL
    Q3TET1
    Related
    ENSMUSP00000133432.2, ENSMUST00000173744.8
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20345
    Kinesin; Kinesin motor domain
  3. NM_008443.4NP_032469.2  kinesin-like protein KIF3A isoform 1

    See identical proteins and their annotated locations for NP_032469.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK053412, AK084748, AK149180, AV356644, BB752635, BC052707, CJ157264
    Consensus CDS
    CCDS48795.1
    UniProtKB/Swiss-Prot
    P28741, Q7TSZ7
    Related
    ENSMUSP00000112782.3, ENSMUST00000120613.9
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20345
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53456531..53495075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532325.5XP_006532388.1  kinesin-like protein KIF3A isoform X1

    UniProtKB/TrEMBL
    B1AQZ2
    Related
    ENSMUSP00000113848.3, ENSMUST00000118353.9
    Conserved Domains (3) summary
    TIGR02168
    Location:449615
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam02463
    Location:340717
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_006532328.5XP_006532391.1  kinesin-like protein KIF3A isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:360586
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
  3. XM_006532326.5XP_006532389.1  kinesin-like protein KIF3A isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:340611
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
  4. XM_036156358.1XP_036012251.1  kinesin-like protein KIF3A isoform X4

    Conserved Domains (2) summary
    COG0419
    Location:336564
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RNA

  1. XR_004936793.1 RNA Sequence