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KIF3A kinesin family member 3A [ Homo sapiens (human) ]

Gene ID: 11127, updated on 4-Jun-2020

Summary

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Official Symbol
KIF3Aprovided by HGNC
Official Full Name
kinesin family member 3Aprovided by HGNC
Primary source
HGNC:HGNC:6319
See related
Ensembl:ENSG00000131437 MIM:604683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLA10; KLP-20
Expression
Broad expression in brain (RPKM 20.7), testis (RPKM 8.8) and 19 other tissues See more
Orthologs
mouse all

Genomic context

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See KIF3A in Genome Data Viewer
Location:
5q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132688808..132737563, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132028323..132073265, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene interleukin 13 Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene septin 8 Neighboring gene cyclin I family member 2 Neighboring gene sosondowah ankyrin repeat domain family member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. Johansson E, et al. J Allergy Clin Immunol, 2017 Aug. PMID 28238750, Free PMC Article
  2. Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway. Jiang S, et al. Mol Med Rep, 2016 Sep. PMID 27432616, Free PMC Article
  3. Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. Hoang-Minh LB, et al. Oncotarget, 2016 Feb 9. PMID 26760767, Free PMC Article
  4. KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer. Liu Z, et al. Mol Cancer Res, 2014 Apr. PMID 24413182, Free PMC Article
  5. Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. Kovacic MB, et al. PLoS One, 2011. PMID 21912604, Free PMC Article

See all (81) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of KIF3A suppressed TNBC cell proliferation by repressing the Rb-E2F signaling pathway and inhibited migration and invasion by repressing epithelial-mesenchymal transition. The tumor size was smaller and the number of lung metastatic nodules was lower in KIF3A depletion MDA-MB-231 cell xenograft mice than in the negative control group. In addition, KIF3A overexpression correlated with chemoresistance.
    Title: Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
  2. Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A
    Title: Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
  3. the association of KIF3A is with asthma + eczema. The presence of AR comorbidity did not increase the genetic association of KIF3A with asthma or even with asthma + eczema. Thus, asthma + eczema constitutes a distinct asthmatic phenotype characterized by an association with KIF3A SNPs, which is not strengthened by AR.
    Title: KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
  4. KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma
    Title: KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
  5. A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC
    Title: KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
  6. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport.
    Title: Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.
  7. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules.
    Title: The armadillo protein p0071 controls KIF3 motor transport.
  8. PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer.
    Title: Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β- catenin/MMP7 signalling.
  9. Inhibition of kif3a in the human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) is disrupted primary cilia formation and/or function, and it was shown that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway.
    Title: Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway.
  10. High KIF3A expression is associated with glioblastoma.
    Title: Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of kinesin family member 3A (KIF3A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Changes of IP7 intracellular levels affect HIV-1 Gag release through modulation of AP3B1 and Kif3A interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
ATP-dependent microtubule motor activity, plus-end-directed TAS
Traceable Author Statement
more info
 PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
  
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
centriole-centriole cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
  
microtubule anchoring at centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
  
organelle organization TAS
Traceable Author Statement
more info
 PubMed 
plus-end-directed vesicle transport along microtubule TAS
Traceable Author Statement
more info
 PubMed 
protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
centriole IDA
Inferred from Direct Assay
more info
 PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
ciliary tip TAS
Traceable Author Statement
more info
  
cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
cilium TAS
Traceable Author Statement
more info
  
cytosol TAS
Traceable Author Statement
more info
  
extracellular exosome HDA PubMed 
kinesin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF3A
Names
kinesin family protein 3A
microtubule plus end-directed kinesin motor 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300791.2 → NP_001287720.1  kinesin-like protein KIF3A isoform 1

    See identical proteins and their annotated locations for NP_001287720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004039, AK295089, AW086059, BC045542
    Consensus CDS
    CCDS75296.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    B4DHG8, E9PES4
    Related
    ENSP00000385808.1, ENST00000403231.5
    Conserved Domains (2) summary
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:450 → 616
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001300792.2 → NP_001287721.1  kinesin-like protein KIF3A isoform 2

    See identical proteins and their annotated locations for NP_001287721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AW086059, BC045542
    Consensus CDS
    CCDS75295.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    J3KPF9
    Related
    ENSP00000368009.1, ENST00000378735.5
    Conserved Domains (2) summary
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:358 → 592
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_007054.7 → NP_008985.3  kinesin-like protein KIF3A isoform 3

    See identical proteins and their annotated locations for NP_008985.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AK313359, AW086059, BC020890
    Consensus CDS
    CCDS34235.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    Q05CT3
    Related
    ENSP00000368020.3, ENST00000378746.8
    Conserved Domains (2) summary
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:340 → 589
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132688808..132737563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714526.4 → XP_006714589.1  kinesin-like protein KIF3A isoform X1

    Conserved Domains (4) summary
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20 → 345
    Kinesin; Kinesin motor domain
    cd16269
    Location:597 → 608
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:448 → 611
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_017008995.2 → XP_016864484.1  kinesin-like protein KIF3A isoform X2

  3. XM_017008996.2 → XP_016864485.1  kinesin-like protein KIF3A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y496.4 GenPept UniProtKB/Swiss-Prot:Q9Y496

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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