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KIF3A kinesin family member 3A [ Homo sapiens (human) ]

Gene ID: 11127, updated on 4-Jun-2020

Summary

Official Symbol
KIF3Aprovided by HGNC
Official Full Name
kinesin family member 3Aprovided by HGNC
Primary source
HGNC:HGNC:6319
See related
Ensembl:ENSG00000131437 MIM:604683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLA10; KLP-20
Expression
Broad expression in brain (RPKM 20.7), testis (RPKM 8.8) and 19 other tissues See more
Orthologs

Genomic context

See KIF3A in Genome Data Viewer
Location:
5q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132688808..132737563, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132028323..132073265, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene interleukin 13 Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene septin 8 Neighboring gene cyclin I family member 2 Neighboring gene sosondowah ankyrin repeat domain family member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kinesin family member 3A (KIF3A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Changes of IP7 intracellular levels affect HIV-1 Gag release through modulation of AP3B1 and Kif3A interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed TAS
Traceable Author Statement
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole-centriole cohesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
microtubule anchoring at centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
organelle organization TAS
Traceable Author Statement
more info
PubMed 
plus-end-directed vesicle transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary tip TAS
Traceable Author Statement
more info
 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF3A
Names
kinesin family protein 3A
microtubule plus end-directed kinesin motor 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300791.2NP_001287720.1  kinesin-like protein KIF3A isoform 1

    See identical proteins and their annotated locations for NP_001287720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004039, AK295089, AW086059, BC045542
    Consensus CDS
    CCDS75296.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    B4DHG8, E9PES4
    Related
    ENSP00000385808.1, ENST00000403231.5
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:450616
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001300792.2NP_001287721.1  kinesin-like protein KIF3A isoform 2

    See identical proteins and their annotated locations for NP_001287721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AW086059, BC045542
    Consensus CDS
    CCDS75295.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    J3KPF9
    Related
    ENSP00000368009.1, ENST00000378735.5
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:358592
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_007054.7NP_008985.3  kinesin-like protein KIF3A isoform 3

    See identical proteins and their annotated locations for NP_008985.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AK313359, AW086059, BC020890
    Consensus CDS
    CCDS34235.1
    UniProtKB/Swiss-Prot
    Q9Y496
    UniProtKB/TrEMBL
    Q05CT3
    Related
    ENSP00000368020.3, ENST00000378746.8
    Conserved Domains (2) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    cl25732
    Location:340589
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132688808..132737563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714526.4XP_006714589.1  kinesin-like protein KIF3A isoform X1

    Conserved Domains (4) summary
    cd01371
    Location:13345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20345
    Kinesin; Kinesin motor domain
    cd16269
    Location:597608
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:448611
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_017008995.2XP_016864484.1  kinesin-like protein KIF3A isoform X2

  3. XM_017008996.2XP_016864485.1  kinesin-like protein KIF3A isoform X3

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