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KIF3A kinesin family member 3A [ Homo sapiens (human) ]

Gene ID: 11127, updated on 23-Nov-2023

Summary

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Official Symbol
KIF3Aprovided by HGNC
Official Full Name
kinesin family member 3Aprovided by HGNC
Primary source
HGNC:HGNC:6319
See related
Ensembl:ENSG00000131437 MIM:604683; AllianceGenome:HGNC:6319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLA10; KLP-20
Summary
Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole and centrosome. Part of kinesin II complex. Colocalizes with spindle microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 20.7), testis (RPKM 8.8) and 19 other tissues See more
Orthologs
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Genomic context

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See KIF3A in Genome Data Viewer
Location:
5q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132688812..132737546, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133208481..133257281, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132028323..132073238, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132000651-132001178 Neighboring gene interleukin 13 Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23096 Neighboring gene septin 8 Neighboring gene cyclin I family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16337 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150138-132150638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150639-132151139 Neighboring gene sosondowah ankyrin repeat domain family member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway. Liu S, et al. Sci Prog, 2023 Jan-Mar. PMID 36594221, Free PMC Article
  2. Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo. Zhou Q, et al. FEBS Open Bio, 2021 May. PMID 31774623, Free PMC Article
  3. KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. Johansson E, et al. J Allergy Clin Immunol, 2017 Aug. PMID 28238750, Free PMC Article
  4. Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway. Jiang S, et al. Mol Med Rep, 2016 Sep. PMID 27432616, Free PMC Article
  5. Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. Hoang-Minh LB, et al. Oncotarget, 2016 Feb 9. PMID 26760767, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells.
    Title: Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells.
  2. Kinesin family member 3A induces related diseases via wingless-related integration site/beta-catenin signaling pathway.
    Title: Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway.
  3. lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
    Title: lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
  4. Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
    Title: Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
  5. Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.
    Title: Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.
  6. Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
    Title: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
  7. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
    Title: Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
  8. Silencing of KIF3A suppressed TNBC cell proliferation by repressing the Rb-E2F signaling pathway and inhibited migration and invasion by repressing epithelial-mesenchymal transition. The tumor size was smaller and the number of lung metastatic nodules was lower in KIF3A depletion MDA-MB-231 cell xenograft mice than in the negative control group. In addition, KIF3A overexpression correlated with chemoresistance.
    Title: Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
  9. Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A
    Title: Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
  10. the association of KIF3A is with asthma + eczema. The presence of AR comorbidity did not increase the genetic association of KIF3A with asthma or even with asthma + eczema. Thus, asthma + eczema constitutes a distinct asthmatic phenotype characterized by an association with KIF3A SNPs, which is not strengthened by AR.
    Title: KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of kinesin family member 3A (KIF3A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Changes of IP7 intracellular levels affect HIV-1 Gag release through modulation of AP3B1 and Kif3A interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spectrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole-centriole cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule anchoring at centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organelle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in plus-end-directed vesicle transport along microtubule TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary tip TAS
Traceable Author Statement
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF3A
Names
kinesin family protein 3A
microtubule plus end-directed kinesin motor 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300791.2 → NP_001287720.1  kinesin-like protein KIF3A isoform 1

    See identical proteins and their annotated locations for NP_001287720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004039, AK295089, AW086059, BC045542
    Consensus CDS
    CCDS75296.1
    UniProtKB/TrEMBL
    B4DHG8, E9PES4
    Related
    ENSP00000385808.1, ENST00000403231.6
    Conserved Domains (2) summary
    TIGR02168
    Location:450 → 616
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

  2. NM_001300792.2 → NP_001287721.1  kinesin-like protein KIF3A isoform 2

    See identical proteins and their annotated locations for NP_001287721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AW086059, BC045542
    Consensus CDS
    CCDS75295.1
    UniProtKB/TrEMBL
    B4DHG8, J3KPF9
    Related
    ENSP00000368009.1, ENST00000378735.5
    Conserved Domains (2) summary
    TIGR02168
    Location:358 → 592
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

  3. NM_007054.7 → NP_008985.3  kinesin-like protein KIF3A isoform 3

    See identical proteins and their annotated locations for NP_008985.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB209780, AC004039, AK313359, AW086059, BC020890
    Consensus CDS
    CCDS34235.1
    UniProtKB/Swiss-Prot
    A8MSW9, Q59EN1, Q86XE9, Q9Y496, Q9Y6V4
    UniProtKB/TrEMBL
    B4DHG8
    Related
    ENSP00000368020.3, ENST00000378746.8
    Conserved Domains (2) summary
    TIGR02168
    Location:340 → 589
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    132688812..132737546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008996.3 → XP_016864485.1  kinesin-like protein KIF3A isoform X2

    UniProtKB/TrEMBL
    B4DHG8

  2. XM_006714526.5 → XP_006714589.1  kinesin-like protein KIF3A isoform X1

    UniProtKB/TrEMBL
    B4DHG8
    Conserved Domains (4) summary
    cd01371
    Location:13 → 345
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:20 → 345
    Kinesin; Kinesin motor domain
    cd16269
    Location:597 → 608
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:448 → 611
    GBP_C; Guanylate-binding protein, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    133208481..133257281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351517.1 → XP_054207492.1  kinesin-like protein KIF3A isoform X1

    UniProtKB/TrEMBL
    B4DHG8

  2. XM_054351518.1 → XP_054207493.1  kinesin-like protein KIF3A isoform X2

    UniProtKB/TrEMBL
    B4DHG8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y496.4 GenPept UniProtKB/Swiss-Prot:Q9Y496

Gene LinkOut

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