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Kif2a kinesin family member 2A [ Mus musculus (house mouse) ]

Gene ID: 16563, updated on 2-Nov-2024

Summary

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Official Symbol
Kif2aprovided by MGI
Official Full Name
kinesin family member 2Aprovided by MGI
Primary source
MGI:MGI:108390
See related
Ensembl:ENSMUSG00000021693 AllianceGenome:MGI:108390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif2; Kns2; M-kinesin; C530030B14Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in dendritic transport. Located in sperm principal piece. Is active in GABA-ergic synapse. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 12.1), frontal lobe adult (RPKM 11.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Kif2a in Genome Data Viewer
Location:
13 D2.1; 13 58.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (107095504..107158931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106958996..107022355, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene importin 11 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene predicted gene, 57603 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558 Neighboring gene STARR-seq mESC enhancer starr_35572 Neighboring gene STARR-seq mESC enhancer starr_35573 Neighboring gene STARR-positive B cell enhancer ABC_E5414 Neighboring gene predicted gene, 31715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation. Santama N, et al. EMBO J, 1998 Oct 15. PMID 9774330, Free PMC Article
  2. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Homma N, et al. Cell, 2003 Jul 25. PMID 12887924
  3. Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches. Noda Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307638, Free PMC Article
  4. The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo. Groner AC, et al. J Biol Chem, 2012 Jul 20. PMID 22605343, Free PMC Article
  5. KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte. Chen MH, et al. Sci Rep, 2016 Dec 19. PMID 27991556, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF2A deficiency causes early-onset neurodegeneration.
    Title: KIF2A deficiency causes early-onset neurodegeneration.
  2. The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
    Title: The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
  3. KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
    Title: KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
  4. Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation.
    Title: Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation.
  5. Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
    Title: Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
  6. These results suggested that postnatal KIF2A is a key length regulator of DGC developing neurites and is involved in the establishment of precise postnatal hippocampal wiring.
    Title: KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.
  7. Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
    Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
  8. Heterodimeric KIF3AC and KIF3AB, two members of the mammalian kinesin-2 family, generate force for microtubule plus end-directed cargo transport. This study reveals the impact of heterodimerization of the motor polypeptides for microtubule association to start the processive run and the fundamental differences in the motile properties of KIF3C compared with KIF3A and KIF3B.
    Title: Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run.
  9. These data indicate that KIF2A regulates the spindle assembly, asymmetric cytokinesis and the metaphase I-anaphase I transition in mouse oocyte.
    Title: KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte.
  10. Kif2a may act as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome congression, and thus cell cycle progression during mouse oocyte meiotic maturation.
    Title: Kif2a regulates spindle organization and cell cycle progression in meiotic oocytes.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in dendritic transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF2A
Names
kinesin heavy chain member 2
kinesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145779.1 → NP_001139251.1  kinesin-like protein KIF2A isoform 2

    See identical proteins and their annotated locations for NP_001139251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and in the 3' coding region, compared to variant 1. An upstream start codon with a strong Kozak signal is used by this variant. The predicted protein (isoform 2) has a longer and distinct N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC154257, AC154328, AK016720, AK037037, CF581603
    Consensus CDS
    CCDS49356.1
    UniProtKB/Swiss-Prot
    O54744, P28740, Q91W03
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000022204.10, ENSMUST00000022204.16
    Conserved Domains (1) summary
    cd01367
    Location:222 → 550
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. NM_001374727.1 → NP_001361656.1  kinesin-like protein KIF2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    Consensus CDS
    CCDS88521.1
    UniProtKB/TrEMBL
    E0CZ72, F8VQ42
    Related
    ENSMUSP00000125644.2, ENSMUST00000159772.8
    Conserved Domains (1) summary
    cd01367
    Location:222 → 550
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  3. NM_001378936.1 → NP_001365865.1  kinesin-like protein KIF2A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000113921.3, ENSMUST00000117423.9
    Conserved Domains (1) summary
    cd01367
    Location:176 → 504
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  4. NM_001378937.1 → NP_001365866.1  kinesin-like protein KIF2A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  5. NM_001378938.1 → NP_001365867.1  kinesin-like protein KIF2A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  6. NM_001378939.1 → NP_001365868.1  kinesin-like protein KIF2A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:195 → 523
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  7. NM_001378940.1 → NP_001365869.1  kinesin-like protein KIF2A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000113361.2, ENSMUST00000117539.8
    Conserved Domains (1) summary
    cd01367
    Location:203 → 531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  8. NM_008442.2 → NP_032468.2  kinesin-like protein KIF2A isoform 1

    See identical proteins and their annotated locations for NP_032468.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC154257, AC154328, AK016720, AK037037, BB622253, BE863830, CF581603
    Consensus CDS
    CCDS26759.1
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000112715.2, ENSMUST00000122233.8
    Conserved Domains (2) summary
    smart00129
    Location:195 → 531
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:195 → 523
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    107095504..107158931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157877.1 → XP_036013770.1  kinesin-like protein KIF2A isoform X1

    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:176 → 504
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

  2. XM_036157878.1 → XP_036013771.1  kinesin-like protein KIF2A isoform X2

    Conserved Domains (1) summary
    cd01367
    Location:222 → 536
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RNA

  1. XR_004937942.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28740.2 GenPept UniProtKB/Swiss-Prot:P28740

Gene LinkOut

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