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Kif2a kinesin family member 2A [ Mus musculus (house mouse) ]

Gene ID: 16563, updated on 18-Apr-2024

Summary

Official Symbol
Kif2aprovided by MGI
Official Full Name
kinesin family member 2Aprovided by MGI
Primary source
MGI:MGI:108390
See related
Ensembl:ENSMUSG00000021693 AllianceGenome:MGI:108390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif2; Kns2; M-kinesin; C530030B14Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic spindle assembly; and regulation of cell migration. Predicted to act upstream of or within cell differentiation; cell division; and nervous system development. Located in sperm principal piece. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 12.1), frontal lobe adult (RPKM 11.5) and 18 other tissues See more
Orthologs
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Genomic context

Location:
13 D2.1; 13 58.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (107095504..107158931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106958996..107022355, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene importin 11 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene predicted gene, 57603 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558 Neighboring gene STARR-seq mESC enhancer starr_35572 Neighboring gene STARR-seq mESC enhancer starr_35573 Neighboring gene STARR-positive B cell enhancer ABC_E5414 Neighboring gene predicted gene, 31715

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF2A
Names
kinesin heavy chain member 2
kinesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145779.1NP_001139251.1  kinesin-like protein KIF2A isoform 2

    See identical proteins and their annotated locations for NP_001139251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and in the 3' coding region, compared to variant 1. An upstream start codon with a strong Kozak signal is used by this variant. The predicted protein (isoform 2) has a longer and distinct N-terminus and a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC154257, AC154328, AK016720, AK037037, CF581603
    Consensus CDS
    CCDS49356.1
    UniProtKB/Swiss-Prot
    O54744, P28740, Q91W03
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000022204.10, ENSMUST00000022204.16
    Conserved Domains (1) summary
    cd01367
    Location:222550
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  2. NM_001374727.1NP_001361656.1  kinesin-like protein KIF2A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    Consensus CDS
    CCDS88521.1
    UniProtKB/TrEMBL
    E0CZ72, F8VQ42
    Related
    ENSMUSP00000125644.2, ENSMUST00000159772.8
    Conserved Domains (1) summary
    cd01367
    Location:222550
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  3. NM_001378936.1NP_001365865.1  kinesin-like protein KIF2A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000113921.3, ENSMUST00000117423.9
    Conserved Domains (1) summary
    cd01367
    Location:176504
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  4. NM_001378937.1NP_001365866.1  kinesin-like protein KIF2A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  5. NM_001378938.1NP_001365867.1  kinesin-like protein KIF2A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  6. NM_001378939.1NP_001365868.1  kinesin-like protein KIF2A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:195523
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  7. NM_001378940.1NP_001365869.1  kinesin-like protein KIF2A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154257, AC154328
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000113361.2, ENSMUST00000117539.8
    Conserved Domains (1) summary
    cd01367
    Location:203531
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  8. NM_008442.2NP_032468.2  kinesin-like protein KIF2A isoform 1

    See identical proteins and their annotated locations for NP_032468.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC154257, AC154328, AK016720, AK037037, BB622253, BE863830, CF581603
    Consensus CDS
    CCDS26759.1
    UniProtKB/TrEMBL
    F8VQ42
    Related
    ENSMUSP00000112715.2, ENSMUST00000122233.8
    Conserved Domains (2) summary
    smart00129
    Location:195531
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:195523
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    107095504..107158931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157877.1XP_036013770.1  kinesin-like protein KIF2A isoform X1

    UniProtKB/TrEMBL
    F8VQ42
    Conserved Domains (1) summary
    cd01367
    Location:176504
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  2. XM_036157878.1XP_036013771.1  kinesin-like protein KIF2A isoform X2

    Conserved Domains (1) summary
    cd01367
    Location:222536
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RNA

  1. XR_004937942.1 RNA Sequence