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KIF2A kinesin family member 2A [ Homo sapiens (human) ]

Gene ID: 3796, updated on 9-Aug-2021

Summary

Official Symbol
KIF2Aprovided by HGNC
Official Full Name
kinesin family member 2Aprovided by HGNC
Primary source
HGNC:HGNC:6318
See related
Ensembl:ENSG00000068796 MIM:602591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HK2; KIF2; CDCBM3
Summary
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 17.8), brain (RPKM 16.2) and 24 other tissues See more
Orthologs
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Genomic context

See KIF2A in Genome Data Viewer
Location:
5q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (62306167..62391025)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61602033..61686852)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378998 Neighboring gene RN7SK pseudogene 157 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1488 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene importin 11 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of kinesin heavy chain member 2A (KIF2A) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of centriolar subdistal appendage IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF2A
Names
Kinesin, heavy chain, 2
kinesin heavy chain member 2A
kinesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042185.1 RefSeqGene

    Range
    5001..86023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098511.3NP_001091981.1  kinesin-like protein KIF2A isoform 2

    See identical proteins and their annotated locations for NP_001091981.1

    Status: REVIEWED

    Source sequence(s)
    AC016637, AC034242
    Consensus CDS
    CCDS47216.1
    UniProtKB/Swiss-Prot
    O00139
    Related
    ENSP00000385000.3, ENST00000407818.8
    Conserved Domains (2) summary
    smart00129
    Location:223559
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:223551
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  2. NM_001243952.2NP_001230881.2  kinesin-like protein KIF2A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC016637, AC034242, BC047544
    Consensus CDS
    CCDS58949.1
    Related
    ENSP00000370493.3, ENST00000381103.7
    Conserved Domains (1) summary
    cd01367
    Location:196524
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  3. NM_001243953.2NP_001230882.1  kinesin-like protein KIF2A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC016637, AI652174, AK315866, DB452624, DB456309
    UniProtKB/TrEMBL
    B0AZS5
    Related
    ENSP00000501719.1, ENST00000676271.1
    Conserved Domains (2) summary
    smart00129
    Location:204539
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:204532
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
  4. NM_004520.5NP_004511.2  kinesin-like protein KIF2A isoform 1

    See identical proteins and their annotated locations for NP_004511.2

    Status: REVIEWED

    Source sequence(s)
    AC016637, AI652174, DB456309, EF560728
    Consensus CDS
    CCDS3980.2
    UniProtKB/Swiss-Prot
    O00139
    Related
    ENSP00000385622.3, ENST00000401507.7
    Conserved Domains (2) summary
    smart00129
    Location:223558
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01367
    Location:223551
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    62306167..62391025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001742064.2 RNA Sequence

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