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Kif1c kinesin family member 1C [ Mus musculus (house mouse) ]

Gene ID: 16562, updated on 18-Apr-2024

Summary

Official Symbol
Kif1cprovided by MGI
Official Full Name
kinesin family member 1Cprovided by MGI
Primary source
MGI:MGI:1098260
See related
Ensembl:ENSMUSG00000020821 AllianceGenome:MGI:1098260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ltxs1; Orch3; D11Bwg1349e; B430105J22Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; brain meninges; cerebral cortex; and vibrissa. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 50.0), colon adult (RPKM 41.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
11 B3; 11 43.21 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70591170..70622796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70700396..70731970)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene microRNA 6925 Neighboring gene predicted gene 12320 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
autoimmune orchitis resistance 3
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28766

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kinesin-like protein KIF1C
Names
N-3 kinsin
kinesin 1C
kinesin superfamily protein 1C
lethal factor toxin susceptibility 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153103.2NP_694743.2  kinesin-like protein KIF1C

    See identical proteins and their annotated locations for NP_694743.2

    Status: VALIDATED

    Source sequence(s)
    AB074017, AK029250, AK046574, AL596117
    Consensus CDS
    CCDS24965.1
    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Related
    ENSMUSP00000092075.5, ENSMUST00000094499.11
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70591170..70622796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156353.1XP_036012246.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  2. XM_006532321.5XP_006532384.1  kinesin-like protein KIF1C isoform X2

    See identical proteins and their annotated locations for XP_006532384.1

    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Related
    ENSMUSP00000099614.2, ENSMUST00000102554.8
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  3. XM_036156351.1XP_036012244.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  4. XM_006532323.5XP_006532386.1  kinesin-like protein KIF1C isoform X4

    Conserved Domains (2) summary
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  5. XM_036156354.1XP_036012247.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Related
    ENSMUSP00000072048.6, ENSMUST00000072187.12
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  6. XM_006532322.5XP_006532385.1  kinesin-like protein KIF1C isoform X2

    See identical proteins and their annotated locations for XP_006532385.1

    UniProtKB/Swiss-Prot
    O35071, Q5SX62
    UniProtKB/TrEMBL
    Q8VI89
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  7. XM_036156352.1XP_036012245.1  kinesin-like protein KIF1C isoform X1

    UniProtKB/TrEMBL
    E9Q9B0, Q6A011
    Conserved Domains (3) summary
    cd00060
    Location:499599
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4355
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:352522
    Kinesin_assoc; Kinesin-associated
  8. XM_036156355.1XP_036012248.1  kinesin-like protein KIF1C isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:14114
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam16183
    Location:1137
    Kinesin_assoc; Kinesin-associated
  9. XM_036156356.1XP_036012249.1  kinesin-like protein KIF1C isoform X5

RNA

  1. XR_003949317.2 RNA Sequence