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LRRN4 leucine rich repeat neuronal 4 [ Homo sapiens (human) ]

Gene ID: 164312, updated on 22-Sep-2022

Summary

Official Symbol
LRRN4provided by HGNC
Official Full Name
leucine rich repeat neuronal 4provided by HGNC
Primary source
HGNC:HGNC:16208
See related
Ensembl:ENSG00000125872 MIM:619706; AllianceGenome:HGNC:16208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLRR4; NLRR-4; C20orf75; dJ1056H1.1
Summary
Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung (RPKM 6.4) and kidney (RPKM 1.0) See more
Orthologs
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Genomic context

See LRRN4 in Genome Data Viewer
Location:
20p12.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (6040546..6054060, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (6080866..6094379, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (6021192..6034706, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene MCM8 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 498, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14083 Neighboring gene cardiolipin synthase 1 Neighboring gene uncharacterized LOC124904865 Neighboring gene FERM domain containing kindlin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ23994, MGC25027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in long-term memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat neuronal protein 4
Names
neuronal leucine-rich repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152611.5NP_689824.2  leucine-rich repeat neuronal protein 4 precursor

    See identical proteins and their annotated locations for NP_689824.2

    Status: VALIDATED

    Source sequence(s)
    AA464555, AK290123, BC027720, BP252017
    Consensus CDS
    CCDS13097.1
    UniProtKB/Swiss-Prot
    Q8WUT4, Q9H419
    Related
    ENSP00000368135.4, ENST00000378858.5
    Conserved Domains (6) summary
    PHA03255
    Location:313491
    PHA03255; BDLF3; Provisional
    COG4886
    Location:224311
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00063
    Location:580676
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00116
    Location:69213
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:77100
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123178
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    6040546..6054060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    6080866..6094379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)