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Itgb2 integrin beta 2 [ Mus musculus (house mouse) ]

Gene ID: 16414, updated on 18-Apr-2024

Summary

Official Symbol
Itgb2provided by MGI
Official Full Name
integrin beta 2provided by MGI
Primary source
MGI:MGI:96611
See related
Ensembl:ENSMUSG00000000290 AllianceGenome:MGI:96611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2E6; LAD; Cd18; Lfa1; MF17; LCAMB
Summary
Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 72.3), spleen adult (RPKM 63.3) and 12 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 39.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77366164..77401542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77530329..77565708)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene RIKEN cDNA 2810425M01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:76985118-76985305 Neighboring gene predicted gene, 36040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:77000632-77000867 Neighboring gene pituitary tumor-transforming 1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_27206 Neighboring gene STARR-positive B cell enhancer ABC_E6875 Neighboring gene small ubiquitin-like modifier 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (5) 
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ICAM-3 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amyloid-beta binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to cargo receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables complement component C3b binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin alphaL-beta2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphaM-beta2 complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
integrin beta-2
Names
Mac-1 beta
cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
complement receptor C3 subunit beta
lymphocyte function associated antigen 1
macrophage antigen-1 beta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008404.5NP_032430.2  integrin beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032430.2

    Status: VALIDATED

    Source sequence(s)
    AC153830
    Consensus CDS
    CCDS23956.1
    UniProtKB/Swiss-Prot
    P11835, Q64482
    UniProtKB/TrEMBL
    Q542I8
    Related
    ENSMUSP00000000299.8, ENSMUST00000000299.14
    Conserved Domains (3) summary
    pfam00362
    Location:32447
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:626700
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:727767
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RNA

  1. NR_157228.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK161236, AK169587, BY787094
    Related
    ENSMUST00000156644.8
  2. NR_157229.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153830, AK161236, BY787094
    Related
    ENSMUST00000153541.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77366164..77401542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513272.4XP_006513335.1  integrin beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006513335.1

    UniProtKB/Swiss-Prot
    P11835, Q64482
    Conserved Domains (4) summary
    smart00187
    Location:15369
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:548622
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:649689
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:369398
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
  2. XM_006513271.4XP_006513334.1  integrin beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006513334.1

    UniProtKB/Swiss-Prot
    P11835, Q64482
    Conserved Domains (4) summary
    smart00187
    Location:15369
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:548622
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:649689
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:369398
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
  3. XM_017313814.2XP_017169303.1  integrin beta-2 isoform X1

    UniProtKB/Swiss-Prot
    P11835, Q64482
    Conserved Domains (4) summary
    smart00187
    Location:15369
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:548622
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:649689
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:369398
    I-EGF_1; Integrin beta epidermal growth factor like domain 1