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ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 3689, updated on 22-Mar-2020

Summary

Official Symbol
ITGB2provided by HGNC
Official Full Name
integrin subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:6155
See related
Ensembl:ENSG00000160255 MIM:600065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Summary
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in bone marrow (RPKM 117.8), appendix (RPKM 80.8) and 14 other tissues See more
Orthologs

Genomic context

See ITGB2 in Genome Data Viewer
Location:
21q22.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (44885949..44928815, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46305864..46348753, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 3 Neighboring gene PTTG1 interacting protein Neighboring gene uncharacterized LOC107987303 Neighboring gene ITGB2 antisense RNA 1 Neighboring gene uncharacterized LOC112268278 Neighboring gene long intergenic non-protein coding RNA 1547 Neighboring gene uncharacterized LOC107985497 Neighboring gene family with sequence similarity 207 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITGB2 (CD18); predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
env HIV-1 gp160 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat inhibits calcium influx and impairs CAMKII activation elicited via LFA-1 (beta 2 integrin) in NK cells PubMed
tat HIV-1 Tat treatment of monocytes upregulates beta 2 integrins and anti-beta 2 Abs inhibits Tat induced adhesion of monocytes to endothelial monolayers, suggesting a mechanism where monocytes could be inappropriately activated by HIV-1 Tat PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 2 (ITGB2, complement component 3 receptor 3 and 4) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ICAM-3 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion molecule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
complement component C3b binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
protein heterodimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules NAS
Non-traceable Author Statement
more info
PubMed 
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular extravasation IEA
Inferred from Electronic Annotation
more info
 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
leukocyte migration involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
microglial cell activation NAS
Non-traceable Author Statement
more info
PubMed 
natural killer cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron death NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prostaglandin-E synthase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein targeting to membrane NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of superoxide anion generation NAS
Non-traceable Author Statement
more info
PubMed 
receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape NAS
Non-traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell surface HDA PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic region IPI
Inferred from Physical Interaction
more info
PubMed 
external side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular vesicle HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin alphaL-beta2 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alphaM-beta2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex TAS
Traceable Author Statement
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin beta-2
Names
cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)
complement component 3 receptor 3 and 4 subunit
complement receptor C3 beta-subunit
integrin beta chain, beta 2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
leukocyte cell adhesion molecule CD18
leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007270.2 RefSeqGene

    Range
    4966..47886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_76

mRNA and Protein(s)

  1. NM_000211.5NP_000202.3  integrin beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK095992, AK222505, CA447686, M15395
    Consensus CDS
    CCDS13716.1
    UniProtKB/Swiss-Prot
    P05107
    Related
    ENSP00000498780.1, ENST00000652462.1
    Conserved Domains (3) summary
    smart00187
    Location:32447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622699
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:726767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  2. NM_001127491.3NP_001120963.2  integrin beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK095992, AL844908, CA447686, M15395
    Consensus CDS
    CCDS13716.1
    UniProtKB/Swiss-Prot
    P05107
    Related
    ENSP00000347279.4, ENST00000355153.8
    Conserved Domains (3) summary
    smart00187
    Location:32447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622699
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:726767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  3. NM_001303238.2NP_001290167.1  integrin beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001290167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR, uses an alternate splice site in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK303488, AU279404, CA447686, M15395
    UniProtKB/Swiss-Prot
    P05107
    UniProtKB/TrEMBL
    B4E0R1
    Conserved Domains (3) summary
    smart00187
    Location:1378
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:553630
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:657697
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44885949..44928815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724001.2XP_006724064.1  integrin beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006724064.1

    UniProtKB/TrEMBL
    B4E0R1
    Conserved Domains (3) summary
    smart00187
    Location:1378
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:553630
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:657697
    Integrin_b_cyt; Integrin beta cytoplasmic domain
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