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Itgb1bp1 integrin beta 1 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 16413, updated on 5-Jan-2022

Summary

Official Symbol
Itgb1bp1provided by MGI
Official Full Name
integrin beta 1 binding protein 1provided by MGI
Primary source
MGI:MGI:1306802
See related
Ensembl:ENSMUSG00000062352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Icap1; AI449260; AU019480
Summary
Enables protein kinase binding activity. Involved in several processes, including integrin activation; positive regulation of stress fiber assembly; and regulation of cell-substrate adhesion. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Is expressed in left lung and right lung. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis adult (RPKM 30.9), subcutaneous fat pad adult (RPKM 11.0) and 24 other tissues See more
Orthologs
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Genomic context

See Itgb1bp1 in Genome Data Viewer
Location:
12; 12 A1.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21317247..21336285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21267246..21286292, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (21275667..21292098, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5977 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40855 Neighboring gene predicted gene, 25821 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in integrin activation ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin beta-1-binding protein 1
Names
bodenin
integrin cytoplasmic domain-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355609.1NP_001342538.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK007635, AK075577, BE947737, BY085309, CX238278
    Consensus CDS
    CCDS25833.1
    Related
    ENSMUSP00000134627.2, ENSMUST00000173729.8
    Conserved Domains (1) summary
    cl17171
    Location:1199
    PH-like; Pleckstrin homology-like domain
  2. NM_008403.5NP_032429.1  integrin beta-1-binding protein 1

    See identical proteins and their annotated locations for NP_032429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC156032, AK075577, BE947737, BY085309
    Consensus CDS
    CCDS25833.1
    UniProtKB/Swiss-Prot
    O35671
    Related
    ENSMUSP00000075609.5, ENSMUST00000076260.12
    Conserved Domains (1) summary
    cl17171
    Location:1199
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    21317247..21336285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514989.4XP_006515052.1  integrin beta-1-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515052.1

    Conserved Domains (1) summary
    cl17171
    Location:1177
    PH-like; Pleckstrin homology-like domain
  2. XM_006514990.5XP_006515053.1  integrin beta-1-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515053.1

    Conserved Domains (1) summary
    cl17171
    Location:1177
    PH-like; Pleckstrin homology-like domain
  3. XM_011243816.4XP_011242118.1  integrin beta-1-binding protein 1 isoform X2

    Related
    ENSMUSP00000134508.2, ENSMUST00000172834.2
    Conserved Domains (1) summary
    cl17171
    Location:1177
    PH-like; Pleckstrin homology-like domain
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