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ITGB1BP1 integrin subunit beta 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9270, updated on 13-Mar-2020

Summary

Official Symbol
ITGB1BP1provided by HGNC
Official Full Name
integrin subunit beta 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:23927
See related
Ensembl:ENSG00000119185 MIM:607153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
Summary
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Broad expression in fat (RPKM 65.6), brain (RPKM 11.2) and 22 other tissues See more
Orthologs

Genomic context

See ITGB1BP1 in Genome Data Viewer
Location:
2p25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (9403475..9423569, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9545810..9563698, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 10317 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene uncharacterized LOC107985850 Neighboring gene ADAM metallopeptidase domain 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686K08158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
integrin activation ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
myoblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell adhesion involved in substrate-bound cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood vessel diameter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
tube formation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
NOT focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin beta-1-binding protein 1
Names
bodenin
integrin cytoplasmic domain-associated protein 1
integrin cytoplasmic domain-associated protein 1-alpha
integrin cytoplasmic domain-associated protein 1-beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319066.2NP_001305995.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC080162, AI144519, AU280516, BC012264, CA428076
    Consensus CDS
    CCDS1662.1
    UniProtKB/Swiss-Prot
    O14713
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  2. NM_001319067.2NP_001305996.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC080162, AI336197, AU280516, BC012264, CA428076
    Consensus CDS
    CCDS1662.1
    UniProtKB/Swiss-Prot
    O14713
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  3. NM_001319068.2NP_001305997.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC080162, BU520903, CA428076
    Consensus CDS
    CCDS1662.1
    UniProtKB/Swiss-Prot
    O14713
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  4. NM_001319069.2NP_001305998.1  integrin beta-1-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate exons compared to variant 3. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC080162, CA428076, DC321859, DC361372
    UniProtKB/TrEMBL
    B4DQY5
    Conserved Domains (1) summary
    cl17171
    Location:7156
    PH-like; Pleckstrin homology-like domain
  5. NM_001319070.2NP_001305999.1  integrin beta-1-binding protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC080162, BY996754, CA428076, DC361372
    Conserved Domains (1) summary
    cl17171
    Location:23128
    PH-like; Pleckstrin homology-like domain
  6. NM_001369744.1NP_001356673.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Related
    ENSP00000353850.3, ENST00000360635.7
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  7. NM_001369745.1NP_001356674.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  8. NM_001369746.1NP_001356675.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  9. NM_001369747.1NP_001356676.1  integrin beta-1-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Related
    ENSP00000419524.1, ENST00000488451.5
    Conserved Domains (1) summary
    cl17171
    Location:1150
    PH-like; Pleckstrin homology-like domain
  10. NM_001369748.1NP_001356677.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  11. NM_001369749.2NP_001356678.1  integrin beta-1-binding protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  12. NM_001369750.1NP_001356679.1  integrin beta-1-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC080162
    Conserved Domains (1) summary
    cl17171
    Location:1150
    PH-like; Pleckstrin homology-like domain
  13. NM_004763.5NP_004754.1  integrin beta-1-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC080162, BC012264, CA428076, DC361372
    Consensus CDS
    CCDS1662.1
    UniProtKB/Swiss-Prot
    O14713
    Related
    ENSP00000347504.4, ENST00000355346.8
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  14. NM_022334.5NP_071729.1  integrin beta-1-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_071729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC080162, BG032225, CA428076, DC361372
    Consensus CDS
    CCDS1663.1
    UniProtKB/Swiss-Prot
    O14713
    Related
    ENSP00000238091.4, ENST00000238091.8
    Conserved Domains (1) summary
    cl17171
    Location:1150
    PH-like; Pleckstrin homology-like domain

RNA

  1. NR_134951.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains two alternate exons in place of the first two exons compared to variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC080162, BC012264, BE146261, CA428076, DB167886
  2. NR_134952.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' end, uses an alternate internal splice junction, and lacks an alternate 3' exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC080162, AK092115, CA428076, DC361372
  3. NR_134953.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' end and lacks an alternate 3' exon compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC080162, CA428076, DA751320, DC361372
  4. NR_134954.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' end and uses an alternate splice junction in the 3' end compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC080162, BQ421551, CA428076, DC361372
  5. NR_134955.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' end and uses an alternate splice junction in the 3' end compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC080162, BC012264, CA428076, DA087859, DC361372
  6. NR_134956.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' end and lacks an alternate internal exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC080162, BX647099, CA428076, DC361372
  7. NR_134957.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' end and lacks an alternate internal exon compared to variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC080162, CA428076, CT002942, DC361372

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    9403475..9423569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711903.3XP_006711966.1  integrin beta-1-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006711966.1

    UniProtKB/Swiss-Prot
    O14713
    Related
    ENSP00000352743.3, ENST00000359712.7
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  2. XM_017005267.1XP_016860756.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O14713
    Conserved Domains (1) summary
    pfam10480
    Location:1200
    ICAP-1_inte_bdg; Beta-1 integrin binding protein
  3. XM_017005270.1XP_016860759.1  integrin beta-1-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    O14713
    Conserved Domains (1) summary
    cl17171
    Location:1150
    PH-like; Pleckstrin homology-like domain
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