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Itga7 integrin alpha 7 [ Mus musculus (house mouse) ]

Gene ID: 16404, updated on 1-Mar-2024

Summary

Official Symbol
Itga7provided by MGI
Official Full Name
integrin alpha 7provided by MGI
Primary source
MGI:MGI:102700
See related
Ensembl:ENSMUSG00000025348 AllianceGenome:MGI:102700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[a]7; alpha7
Summary
This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 28.3), heart adult (RPKM 26.2) and 21 other tissues See more
Orthologs
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Genomic context

See Itga7 in Genome Data Viewer
Location:
10 D3; 10 77.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128769633..128794155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128933421..128958286)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene predicted gene, 25494 Neighboring gene thiol methyltransferase 1B Neighboring gene RIKEN cDNA 9030616G12 gene Neighboring gene olfactory receptor family 10 subfamily P member 22

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to laminin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin alpha7-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alpha7-beta1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330160.2NP_001317089.1  integrin alpha-7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS88118.1
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    Q3TZS3
    Related
    ENSMUSP00000151960.2, ENSMUST00000218290.2
    Conserved Domains (2) summary
    smart00191
    Location:381433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475965
    Integrin_alpha2; Integrin alpha
  2. NM_001406285.1NP_001393214.1  integrin alpha-7 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
  3. NM_001406286.1NP_001393215.1  integrin alpha-7 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122380
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
  4. NM_001406287.1NP_001393216.1  integrin alpha-7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122380
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
  5. NM_008398.3NP_032424.2  integrin alpha-7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032424.2

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24300.1
    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    G3X9Q1
    Related
    ENSMUSP00000096712.3, ENSMUST00000099112.4
    Conserved Domains (2) summary
    smart00191
    Location:377429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471961
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128769633..128794155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244914.2XP_030100774.1  integrin alpha-7 isoform X4

    Conserved Domains (2) summary
    smart00191
    Location:214266
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:308798
    Integrin_alpha2; Integrin alpha
  2. XM_006513270.4XP_006513333.1  integrin alpha-7 isoform X5

    Conserved Domains (2) summary
    smart00191
    Location:213265
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:307797
    Integrin_alpha2; Integrin alpha
  3. XM_036155649.1XP_036011542.1  integrin alpha-7 isoform X6

    Conserved Domains (2) summary
    smart00191
    Location:209261
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:303793
    Integrin_alpha2; Integrin alpha
  4. XM_030244916.2XP_030100776.1  integrin alpha-7 isoform X8

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:377429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471961
    Integrin_alpha2; Integrin alpha
  5. XM_030244915.2XP_030100775.1  integrin alpha-7 isoform X7

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    UniProtKB/TrEMBL
    A0A8V5L190
    Related
    ENSMUSP00000159495.1, ENSMUST00000240553.1
    Conserved Domains (2) summary
    smart00191
    Location:421473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:5151005
    Integrin_alpha2; Integrin alpha
  6. XM_017313813.3XP_017169302.1  integrin alpha-7 isoform X1

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:381433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475965
    Integrin_alpha2; Integrin alpha
  7. XM_006513269.5XP_006513332.1  integrin alpha-7 isoform X2

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:317369
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:411901
    Integrin_alpha2; Integrin alpha
  8. XM_030244913.2XP_030100773.1  integrin alpha-7 isoform X3

    UniProtKB/Swiss-Prot
    O88731, O88732, P70350, Q61737, Q61738, Q61741
    Conserved Domains (2) summary
    smart00191
    Location:313365
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:407897
    Integrin_alpha2; Integrin alpha