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ITGA7 integrin subunit alpha 7 [ Homo sapiens (human) ]

Gene ID: 3679, updated on 17-Jun-2024

Summary

Official Symbol
ITGA7provided by HGNC
Official Full Name
integrin subunit alpha 7provided by HGNC
Primary source
HGNC:HGNC:6143
See related
Ensembl:ENSG00000135424 MIM:600536; AllianceGenome:HGNC:6143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
Expression
Biased expression in fat (RPKM 86.9), heart (RPKM 53.0) and 9 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See ITGA7 in Genome Data Viewer
Location:
12q13.2
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55684568..55716400, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55651197..55683036, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56078352..56106192, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6450 Neighboring gene olfactory receptor family 10 subfamily AE member 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6451 Neighboring gene VISTA enhancer hs2573 Neighboring gene proteasome subunit beta 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56075179-56075854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56078881-56079380 Neighboring gene thiol methyltransferase 1B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:56087579-56088778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4534 Neighboring gene BLOC1S1-RDH5 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56114612-56115240 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56122619-56123225 Neighboring gene retinol dehydrogenase 5 Neighboring gene CD63 molecule Neighboring gene CD63 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle organ development TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IC
Inferred by Curator
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin alpha-7
Names
integrin alpha 7 chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012343.1 RefSeqGene

    Range
    5001..32738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_871

mRNA and Protein(s)

  1. NM_001144996.2NP_001138468.1  integrin alpha-7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB210036, AC009779, AF032108, AY358882, DA398527
    Consensus CDS
    CCDS55832.1
    UniProtKB/TrEMBL
    A0A8I5KSX0
    Related
    ENSP00000452120.1, ENST00000553804.6
    Conserved Domains (2) summary
    smart00191
    Location:381433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475966
    Integrin_alpha2; Integrin alpha
  2. NM_001144997.2NP_001138469.1  integrin alpha-7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC009779
    Consensus CDS
    CCDS44914.1
    UniProtKB/TrEMBL
    G3V2C6
    Related
    ENSP00000393844.2, ENST00000452168.6
    Conserved Domains (2) summary
    smart00191
    Location:284336
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:378869
    Integrin_alpha2; Integrin alpha
  3. NM_001367993.1NP_001354922.1  integrin alpha-7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    G3V2C6
  4. NM_001367994.1NP_001354923.1  integrin alpha-7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009779
  5. NM_001374465.1NP_001361394.1  integrin alpha-7 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    Consensus CDS
    CCDS91703.1
    UniProtKB/TrEMBL
    J3KNV4, Q4LE35
    Related
    ENSP00000343009.6, ENST00000347027.10
    Conserved Domains (2) summary
    smart00191
    Location:377429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471956
    Integrin_alpha2; Integrin alpha
  6. NM_001410977.1NP_001397906.1  integrin alpha-7 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    Consensus CDS
    CCDS91704.1
    UniProtKB/Swiss-Prot
    B4E3U0, C9JMD3, C9JMZ6, O43197, Q13683, Q86W93, Q9NY89, Q9UET0, Q9UEV2
    UniProtKB/TrEMBL
    A0A8I5KSX0
    Related
    ENSP00000452387.1, ENST00000555728.5
  7. NM_001414029.1NP_001400958.1  integrin alpha-7 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    A0A8I5KSX0
  8. NM_001414030.1NP_001400959.1  integrin alpha-7 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    A0A8I5KSX0
  9. NM_001414031.1NP_001400960.1  integrin alpha-7 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    Q4LE35
  10. NM_001414032.1NP_001400961.1  integrin alpha-7 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    A0A8I5KSX0
  11. NM_001414033.1NP_001400962.1  integrin alpha-7 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    Q4LE35
  12. NM_001414034.1NP_001400963.1  integrin alpha-7 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    Q4LE35
  13. NM_001414035.1NP_001400964.1  integrin alpha-7 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC009779
    UniProtKB/TrEMBL
    G3V2C6
  14. NM_002206.3NP_002197.2  integrin alpha-7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002197.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to transcript variant 1. This results in a slightly shorter isoform (2) with a different internal protein segment compared to isoform 1.
    Source sequence(s)
    AB210036, AC009779, AF032108, DA398527
    Consensus CDS
    CCDS8888.1
    UniProtKB/TrEMBL
    Q4LE35
    Related
    ENSP00000257879.7, ENST00000257879.11
    Conserved Domains (2) summary
    smart00191
    Location:377429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471962
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    55684568..55716400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428797.1XP_047284753.1  integrin alpha-7 isoform X5

    UniProtKB/TrEMBL
    G3V2C6
  2. XM_005268844.2XP_005268901.1  integrin alpha-7 isoform X3

    See identical proteins and their annotated locations for XP_005268901.1

    UniProtKB/TrEMBL
    G3V2C6
    Conserved Domains (2) summary
    smart00191
    Location:308360
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:402893
    Integrin_alpha2; Integrin alpha
  3. XM_005268848.2XP_005268905.1  integrin alpha-7 isoform X6

    See identical proteins and their annotated locations for XP_005268905.1

    UniProtKB/TrEMBL
    G3V2C6
    Related
    ENSP00000450578.2, ENST00000557257.2
    Conserved Domains (2) summary
    smart00191
    Location:263315
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:357848
    Integrin_alpha2; Integrin alpha
  4. XM_047428796.1XP_047284752.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  5. XM_047428794.1XP_047284750.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  6. XM_047428793.1XP_047284749.1  integrin alpha-7 isoform X3

    UniProtKB/TrEMBL
    G3V2C6
  7. XM_047428795.1XP_047284751.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  8. XM_017019265.2XP_016874754.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  9. XM_047428798.1XP_047284754.1  integrin alpha-7 isoform X7

    UniProtKB/TrEMBL
    B3KMS6
  10. XM_047428792.1XP_047284748.1  integrin alpha-7 isoform X3

    UniProtKB/TrEMBL
    G3V2C6
  11. XM_005268840.3XP_005268897.1  integrin alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSX0
    Conserved Domains (2) summary
    smart00191
    Location:421473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:5151000
    Integrin_alpha2; Integrin alpha
  12. XM_005268841.3XP_005268898.1  integrin alpha-7 isoform X2

    UniProtKB/TrEMBL
    H0YJ98
    Related
    ENSP00000451039.3, ENST00000557555.3
    Conserved Domains (2) summary
    smart00191
    Location:421473
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:5151006
    Integrin_alpha2; Integrin alpha
  13. XM_047428799.1XP_047284755.1  integrin alpha-7 isoform X8

    UniProtKB/TrEMBL
    G3V2C6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    55651197..55683036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371966.1XP_054227941.1  integrin alpha-7 isoform X5

    UniProtKB/TrEMBL
    G3V2C6
  2. XM_054371962.1XP_054227937.1  integrin alpha-7 isoform X3

    UniProtKB/TrEMBL
    G3V2C6
  3. XM_054371967.1XP_054227942.1  integrin alpha-7 isoform X6

    UniProtKB/TrEMBL
    G3V2C6
  4. XM_054371965.1XP_054227940.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  5. XM_054371964.1XP_054227939.1  integrin alpha-7 isoform X4

    UniProtKB/TrEMBL
    G3V2C6
  6. XM_054371963.1XP_054227938.1  integrin alpha-7 isoform X3

    UniProtKB/TrEMBL
    G3V2C6
  7. XM_054371968.1XP_054227943.1  integrin alpha-7 isoform X7

    UniProtKB/TrEMBL
    B3KMS6
  8. XM_054371961.1XP_054227936.1  integrin alpha-7 isoform X3

    UniProtKB/TrEMBL
    G3V2C6
  9. XM_054371959.1XP_054227934.1  integrin alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KSX0
  10. XM_054371960.1XP_054227935.1  integrin alpha-7 isoform X2

    UniProtKB/TrEMBL
    H0YJ98
  11. XM_054371969.1XP_054227944.1  integrin alpha-7 isoform X8

    UniProtKB/TrEMBL
    G3V2C6