Format

Send to:

Choose Destination

Inpp5b inositol polyphosphate-5-phosphatase B [ Mus musculus (house mouse) ]

Gene ID: 16330, updated on 16-Oct-2021

Summary

Official Symbol
Inpp5bprovided by MGI
Official Full Name
inositol polyphosphate-5-phosphatase Bprovided by MGI
Primary source
MGI:MGI:103257
See related
Ensembl:ENSMUSG00000028894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5PTase; INPP5P; AW260155
Summary
This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in lung adult (RPKM 14.1), thymus adult (RPKM 13.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Inpp5b in Genome Data Viewer
Location:
4 D2.2; 4 57.89 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124635620..124695304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124741827..124801511)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124419122..124478755)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 3 Neighboring gene microRNA 697 Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene microRNA 698 Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
type II inositol 1,4,5-trisphosphate 5-phosphatase
Names
inositol polyphosphate-5-phosphatase, 75 kDa
phosphoinositide 5-phosphatase
NP_032411.3
XP_006502867.1
XP_006502868.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008385.4NP_032411.3  type II inositol 1,4,5-trisphosphate 5-phosphatase precursor

    See identical proteins and their annotated locations for NP_032411.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
    Source sequence(s)
    AK163187, BE988792, BE996479, BG802289, BU610644, BU701664, BU921160, BY778295, CA315937, CA320508, CK390048, DV654857
    Consensus CDS
    CCDS38876.1
    UniProtKB/Swiss-Prot
    Q8K337
    Related
    ENSMUSP00000092375.4, ENSMUST00000094782.10
    Conserved Domains (3) summary
    cd09093
    Location:345638
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:772990
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    pfam16776
    Location:6150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

RNA

  1. NR_126474.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA289577, AA881781, AK004722, AK163187, AL606933, BE988792, BU701664, BY778295, CA315937, CA320508
    Related
    ENSMUST00000184454.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124635620..124695304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502804.3XP_006502867.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006502867.1

    Conserved Domains (3) summary
    cd09093
    Location:346639
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:773991
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    pfam16776
    Location:1150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
  2. XM_006502805.3XP_006502868.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006502868.1

    Conserved Domains (3) summary
    cd09093
    Location:346639
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:773991
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    pfam16776
    Location:1150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

RNA

  1. XR_004941817.1 RNA Sequence

Support Center