Format

Send to:

Choose Destination

INPP5B inositol polyphosphate-5-phosphatase B [ Homo sapiens (human) ]

Gene ID: 3633, updated on 7-Dec-2018

Summary

Official Symbol
INPP5Bprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Bprovided by HGNC
Primary source
HGNC:HGNC:6077
See related
Ensembl:ENSG00000204084 MIM:147264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5PTase
Summary
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in lymph node (RPKM 6.6), ovary (RPKM 6.5) and 25 other tissues See more
Orthologs

Genomic context

See INPP5B in Genome Data Viewer
Location:
1p34.3
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (37860697..37947095, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38326369..38412729, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 122 Neighboring gene yrdC N6-threonylcarbamoyltransferase domain containing Neighboring gene metal regulatory transcription factor 1 Neighboring gene ribosomal protein S2 pseudogene 13 Neighboring gene RNA, U6 small nuclear 584, pseudogene Neighboring gene uncharacterized LOC105378651 Neighboring gene splicing factor 3a subunit 3 Neighboring gene RNA, U6 small nuclear 510, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC65156, MGC71303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
 
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol-1,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
type II inositol 1,4,5-trisphosphate 5-phosphatase
Names
inositol polyphosphate-5-phosphatase, 75kDa
phosphoinositide 5-phosphatase
NP_001284363.1
NP_001337156.1
NP_001337157.1
NP_005531.2
XP_006710684.2
XP_011539694.1
XP_011539695.1
XP_016856695.1
XP_016856696.1
XP_024302530.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297434.1NP_001284363.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK022846, AL929472, BC042529, BC062317, DC398675
    Consensus CDS
    CCDS72760.1
    UniProtKB/Swiss-Prot
    P32019
    UniProtKB/TrEMBL
    B3KMW4
    Related
    ENSP00000362118.1, ENST00000373027.5
    Conserved Domains (2) summary
    cd09093
    Location:101394
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:528748
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
  2. NM_001350227.1NP_001337156.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AK022846, AL929472, BC042529, BC062317, DC398675
    Conserved Domains (2) summary
    cd09093
    Location:45338
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:472692
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
  3. NM_001350228.1NP_001337157.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AK022846, AL603790, AL929472, BC042529, BC062317, M74161
    Conserved Domains (2) summary
    cd09093
    Location:45338
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:472692
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
  4. NM_001365820.1NP_001352749.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:265558
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:692912
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    pfam16776
    Location:6150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
  5. NM_001365821.1NP_001352750.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:263556
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:690910
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    pfam16776
    Location:6148
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
  6. NM_001365822.1NP_001352751.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:243536
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:670890
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    cl17171
    Location:63128
    PH-like; Pleckstrin homology-like domain
  7. NM_001365823.1NP_001352752.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform 6.
    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:200493
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:627847
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:2985
    PH-like; Pleckstrin homology-like domain
  8. NM_001365824.1NP_001352753.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform 6.
    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:200493
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:627847
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:2985
    PH-like; Pleckstrin homology-like domain
  9. NM_001365825.1NP_001352754.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    Conserved Domains (3) summary
    cd09093
    Location:146439
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:573793
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:131
    PH-like; Pleckstrin homology-like domain
  10. NM_005540.3NP_005531.2  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 both encode the same isoform (1).
    Source sequence(s)
    AL603790, AL929472, BC042529, DA125087, M74161
    Consensus CDS
    CCDS41306.1
    UniProtKB/Swiss-Prot
    P32019
    Related
    ENSP00000362115.3, ENST00000373024.7
    Conserved Domains (3) summary
    cd09093
    Location:265558
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:692912
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    pfam16776
    Location:6150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

RNA

  1. NR_158628.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
  2. NR_158629.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
  3. NR_158630.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
  4. NR_158631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    37860697..37947095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001207.2XP_016856696.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X3

    Conserved Domains (3) summary
    cd09093
    Location:146439
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:573793
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:131
    PH-like; Pleckstrin homology-like domain
  2. XM_006710621.4XP_006710684.2  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

    Conserved Domains (3) summary
    cd09093
    Location:200493
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:627847
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:2985
    PH-like; Pleckstrin homology-like domain
  3. XM_011541393.2XP_011539695.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X5

    See identical proteins and their annotated locations for XP_011539695.1

    Conserved Domains (2) summary
    cd09093
    Location:72365
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:499719
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
  4. XM_011541392.2XP_011539694.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X5

    See identical proteins and their annotated locations for XP_011539694.1

    Conserved Domains (2) summary
    cd09093
    Location:72365
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:499719
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
  5. XM_017001206.1XP_016856695.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

  6. XM_024446762.1XP_024302530.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X4

    Conserved Domains (3) summary
    cd09093
    Location:265558
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cl02570
    Location:692729
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    pfam16776
    Location:6150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

RNA

  1. XR_946643.2 RNA Sequence

  2. XR_946644.3 RNA Sequence

Support Center