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OR7D2 olfactory receptor family 7 subfamily D member 2 [ Homo sapiens (human) ]

Gene ID: 162998, updated on 2-Nov-2024

Summary

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Official Symbol
OR7D2provided by HGNC
Official Full Name
olfactory receptor family 7 subfamily D member 2provided by HGNC
Primary source
HGNC:HGNC:8378
See related
Ensembl:ENSG00000188000 AllianceGenome:HGNC:8378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR19-4; OR19-10; HTPCRH03
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See OR7D2 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9178979..9188818)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9305174..9315012)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9289655..9299494)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily G member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13926 Neighboring gene zinc finger protein 317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9270512-9271012 Neighboring gene elongin C pseudogene 29 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9300121-9300643 Neighboring gene olfactory receptor family 7 subfamily E member 16 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 25 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Wilanowski T, et al. Mech Dev, 2002 Jun. PMID 12175488
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859
  3. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
  4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 7D2
Names
olfactory receptor 19-4
olfactory receptor OR19-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386112.1 → NP_001373041.1  olfactory receptor 7D2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC011464
    Consensus CDS
    CCDS32900.1
    UniProtKB/Swiss-Prot
    Q6IFJ7, Q8N133, Q96RA2
    UniProtKB/TrEMBL
    A0A126GVY4
    Related
    ENSP00000492939.1, ENST00000642043.1
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_175883.4 → NP_787079.1  olfactory receptor 7D2

    See identical proteins and their annotated locations for NP_787079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC011464
    Consensus CDS
    CCDS32900.1
    UniProtKB/Swiss-Prot
    Q6IFJ7, Q8N133, Q96RA2
    UniProtKB/TrEMBL
    A0A126GVY4
    Related
    ENSP00000493200.1, ENST00000641288.2
    Conserved Domains (1) summary
    cd15234
    Location:25 → 301
    7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9178979..9188818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438317.1 → XP_047294273.1  olfactory receptor 7D2 isoform X1

    UniProtKB/Swiss-Prot
    Q6IFJ7, Q8N133, Q96RA2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9305174..9315012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320058.1 → XP_054176033.1  olfactory receptor 7D2 isoform X1

    UniProtKB/Swiss-Prot
    Q6IFJ7, Q8N133, Q96RA2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RA2.2 GenPept UniProtKB/Swiss-Prot:Q96RA2

Gene LinkOut

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