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SLFN5 schlafen family member 5 [ Homo sapiens (human) ]

Gene ID: 162394, updated on 28-Aug-2022

Summary

Official Symbol
SLFN5provided by HGNC
Official Full Name
schlafen family member 5provided by HGNC
Primary source
HGNC:HGNC:28286
See related
Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more
Orthologs
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Genomic context

See SLFN5 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35243072..35273655)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36191007..36221590)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33570091..33600674)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene solute carrier family 35 member G3 Neighboring gene uncharacterized LOC105371932 Neighboring gene RING-box protein 2-like Neighboring gene schlafen family member 11 Neighboring gene uncharacterized LOC105371933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with SLFN5 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19764, MGC150611, MGC150612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330183.2NP_001317112.1  schlafen family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022706, AK303632, BQ023439
    Consensus CDS
    CCDS82106.1
    UniProtKB/TrEMBL
    B4E128
    Related
    ENSP00000440537.1, ENST00000542451.1
  2. NM_144975.4NP_659412.3  schlafen family member 5 isoform 1

    See identical proteins and their annotated locations for NP_659412.3

    Status: VALIDATED

    Source sequence(s)
    AC022706, BC125200, BP281007, BX102817
    Consensus CDS
    CCDS32619.1
    UniProtKB/Swiss-Prot
    Q08AF3, Q96A82
    Related
    ENSP00000299977.3, ENST00000299977.9
    Conserved Domains (3) summary
    cl21455
    Location:574657
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:839886
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:34332
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35243072..35273655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36191007..36221590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)