Il12rb1 interleukin 12 receptor, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il12rb1provided by MGI
Official Full Name: interleukin 12 receptor, beta 1provided by MGI
Primary source: MGI:MGI:104579
See related: Ensembl:ENSMUSG00000000791 AllianceGenome:MGI:104579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD212; IL-12R[b]; IL-12R-beta-1
Summary: Contributes to cytokine binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in external side of plasma membrane. Part of interleukin-23 receptor complex. Is expressed in mandible; maxilla; orbito-sphenoid; rib; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 9.3), spleen adult (RPKM 1.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.21 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71261005..71276186)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70808360..70823542)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction.
Title: Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.
In summary, the receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling.
Title: IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.
the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12.
Title: IL12Rβ1ΔTM is a secreted product of il12rb1 that promotes control of extrapulmonary tuberculosis.
Although they share a common subunit, IL-23 and IL-12 receptors are not expressed on the same cell populations.
Title: The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection
Title: Early control of Mycobacterium tuberculosis infection requires il12rb1 expression by rag1-dependent lineages.
IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40)2 dependent mechanism.
Title: Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor β1.
IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis.
Title: Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.
This study delineates a new role of IL-12R beta 1 and IL-12R beta 2 for the expression of iNOS and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases.
Title: IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1.
Results show that direct IL-12 receptor signaling to CD8(+) T cells determines the cell fate decision between short-lived effector cells and memory precursor effector cells, which is dependent on pathogen-induced local cytokine milieu.
Title: Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells.
Data show that the loss of IL-12R engagement does not appear to alter T-cell expansion but leads to their accumulation in secondary lymphoid organs.
Title: IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Il12rb1 gene: The Il12rb1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 427 organisms have orthologs with human gene Il12rb1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-12 receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-12 receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-23 binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-23 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-12 receptor complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 receptor complex	NAS Non-traceable Author Statement more info	PubMed
part_of interleukin-23 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-23 receptor complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-23 receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: interleukin-12 receptor subunit beta-1

Names: IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008353.3 → NP_032379.2 interleukin-12 receptor subunit beta-1 precursor

See identical proteins and their annotated locations for NP_032379.2

Status: VALIDATED

Source sequence(s)

AC162446

Consensus CDS

CCDS22382.1

UniProtKB/Swiss-Prot

Q3UV59, Q60837

Related

ENSMUSP00000000808.8, ENSMUST00000000808.8

Conserved Domains (2) summary

pfam00041
Location:470 → 553

fn3; Fibronectin type III domain

pfam02720
Location:657 → 714

DUF222; Domain of unknown function (DUF222)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71261005..71276186

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509557.4 → XP_006509620.1 interleukin-12 receptor subunit beta-1 isoform X1

Conserved Domains (2) summary

pfam00041
Location:470 → 553

fn3; Fibronectin type III domain

pfam02720
Location:658 → 715

DUF222; Domain of unknown function (DUF222)
XM_006509559.5 → XP_006509622.1 interleukin-12 receptor subunit beta-1 isoform X3

Conserved Domains (1) summary

pfam00041
Location:470 → 553

fn3; Fibronectin type III domain
XM_006509560.5 → XP_006509623.1 interleukin-12 receptor subunit beta-1 isoform X4

UniProtKB/TrEMBL

A0A1D5RL98

Related

ENSMUSP00000148279.2, ENSMUST00000212657.2

Conserved Domains (1) summary

pfam00041
Location:470 → 552

fn3; Fibronectin type III domain
XM_006509558.5 → XP_006509621.1 interleukin-12 receptor subunit beta-1 isoform X2

Conserved Domains (2) summary

pfam00041
Location:449 → 532

fn3; Fibronectin type III domain

pfam02720
Location:637 → 694

DUF222; Domain of unknown function (DUF222)
XM_006509561.5 → XP_006509624.1 interleukin-12 receptor subunit beta-1 isoform X5

See identical proteins and their annotated locations for XP_006509624.1

Conserved Domains (1) summary

pfam00041
Location:305 → 388

fn3; Fibronectin type III domain
XM_011242266.4 → XP_011240568.1 interleukin-12 receptor subunit beta-1 isoform X5

See identical proteins and their annotated locations for XP_011240568.1

Conserved Domains (1) summary

pfam00041
Location:305 → 388

fn3; Fibronectin type III domain
XM_006509562.4 → XP_006509625.1 interleukin-12 receptor subunit beta-1 isoform X6

Conserved Domains (1) summary

pfam00041
Location:191 → 274

fn3; Fibronectin type III domain