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Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 16151, updated on 8-Feb-2024

Summary

Official Symbol
Ikbkgprovided by MGI
Official Full Name
inhibitor of kappaB kinase gammaprovided by MGI
Primary source
MGI:MGI:1338074
See related
Ensembl:ENSMUSG00000004221 AllianceGenome:MGI:1338074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEMO; IKK[g]; 1110037D23Rik
Summary
Enables K63-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in several processes, including anoikis; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and positive regulation of macroautophagy. Acts upstream of or within B cell homeostasis and activation of NF-kappaB-inducing kinase activity. Located in cytoplasm. Is expressed in early conceptus; genitourinary system; and musculature. Used to study Bloch-Sulzberger syndrome and fatty liver disease. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; immunodeficiency 33; and learning disability. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 3.8), bladder adult (RPKM 3.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ikbkg in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73436883..73498013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74393233..74456792)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050 Neighboring gene predicted gene, 54057 Neighboring gene CTAG2 like 1 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase subunit gamma
IKK-gamma
IKKAP1
IKKG
NF-kappa-B essential modifier
ikB kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of nuclear factor kappa-B kinase subunit gamma
mFIP-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

    See identical proteins and their annotated locations for NP_001129539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL669976, AY112937
    Consensus CDS
    CCDS53108.1
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000004330.4, ENSMUST00000004330.10
    Conserved Domains (4) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:67303
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:62128
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:404429
    zf_C2H2_10; C2H2 type zinc-finger
  2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
    Source sequence(s)
    AK037020, AL669976, AY112937
    UniProtKB/TrEMBL
    Q7TSS3, Q8VC91
    Conserved Domains (3) summary
    cd09803
    Location:268354
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:185297
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL669976, AY112937, CN701499
    Consensus CDS
    CCDS53109.1
    UniProtKB/TrEMBL
    E9Q2Y3
    Related
    ENSMUSP00000109765.3, ENSMUST00000114130.9
    Conserved Domains (3) summary
    cd09803
    Location:263349
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:56123
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:180292
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_001154895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CN717929
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Related
    ENSMUSP00000126770.2, ENSMUST00000164101.8
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger
  5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_001154896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CV556906
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000136573.2, ENSMUST00000180230.8
    Conserved Domains (4) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49284
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:385410
    zf_C2H2_10; C2H2 type zinc-finger
  6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_034677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AL669976, AY112937, BY768708
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Related
    ENSMUSP00000109762.2, ENSMUST00000114127.8
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger
  7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_848705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, BY768708
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000064017.4, ENSMUST00000064407.10
    Conserved Domains (4) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49284
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:385410
    zf_C2H2_10; C2H2 type zinc-finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73436883..73498013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527848.5XP_006527911.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_006527911.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (4) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:67303
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:62128
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:404429
    zf_C2H2_10; C2H2 type zinc-finger
  2. XM_006527852.4XP_006527915.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527915.1

    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger
  3. XM_006527853.5XP_006527916.1  NF-kappa-B essential modulator isoform X4

    See identical proteins and their annotated locations for XP_006527916.1

    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000109764.3, ENSMUST00000114129.9
    Conserved Domains (4) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49284
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:385410
    zf_C2H2_10; C2H2 type zinc-finger
  4. XM_006527847.5XP_006527910.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_006527910.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (4) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:67303
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:62128
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:404429
    zf_C2H2_10; C2H2 type zinc-finger
  5. XM_006527850.4XP_006527913.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527913.1

    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Related
    ENSMUSP00000109763.2, ENSMUST00000114128.8
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger
  6. XM_006527851.4XP_006527914.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527914.1

    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger
  7. XM_006527849.3XP_006527912.1  NF-kappa-B essential modulator isoform X2

    Conserved Domains (4) summary
    cd09803
    Location:257343
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:55291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:50116
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:392417
    zf_C2H2_10; C2H2 type zinc-finger
  8. XM_011247527.4XP_011245829.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_011245829.1

    UniProtKB/Swiss-Prot
    O88522, Q924H4
    Conserved Domains (4) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    TIGR02168
    Location:49285
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11577
    Location:44110
    NEMO; NF-kappa-B essential modulator NEMO
    pfam18414
    Location:386411
    zf_C2H2_10; C2H2 type zinc-finger