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Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 16151, updated on 4-Feb-2018
Official Symbol
Ikbkgprovided by MGI
Official Full Name
inhibitor of kappaB kinase gammaprovided by MGI
Primary source
MGI:MGI:1338074
See related
Ensembl:ENSMUSG00000004221 Vega:OTTMUSG00000017732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
Expression
Ubiquitous expression in liver E18 (RPKM 3.8), bladder adult (RPKM 3.7) and 28 other tissues See more
Orthologs
Location:
X; X A7.3
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74393291..74456792)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71638630..71699117)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene 6880 Neighboring gene ribosomal protein S2 pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of NF-kappaB-inducing kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase subunit gamma
IKK-gamma
IKKAP1
IKKG
NF-kappa-B essential modifier
ikB kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of nuclear factor kappa-B kinase subunit gamma
mFIP-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

    See identical proteins and their annotated locations for NP_001129539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL669976, AY112937
    Consensus CDS
    CCDS53108.1
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000004330.3, ENSMUST00000004330.9
    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:186298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
    Source sequence(s)
    AK037020, AL669976, AY112937
    UniProtKB/TrEMBL
    Q7TSS3, Q8VC91
    Conserved Domains (3) summary
    cd09803
    Location:268354
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:185297
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL669976, AY112937, CN701499
    Consensus CDS
    CCDS53109.1
    UniProtKB/TrEMBL
    E9Q2Y3, Q7TSS3
    Related
    ENSMUSP00000109765.2, ENSMUST00000114130.8
    Conserved Domains (3) summary
    cd09803
    Location:263349
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:56123
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:180292
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_001154895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CN717929
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000126770.1, ENSMUST00000164101.7
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_001154896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CV556906
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000136573.1, ENSMUST00000180230.7
    Conserved Domains (3) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:167279
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_034677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AL669976, AY112937, BY768708
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000109762.1, OTTMUSP00000021360, ENSMUST00000114127.7, OTTMUST00000047324
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_848705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, BY768708
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000064017.3, OTTMUSP00000021361, ENSMUST00000064407.9, OTTMUST00000047325
    Conserved Domains (3) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:167279
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    74393291..74456792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527852.2XP_006527915.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527915.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  2. XM_006527848.3XP_006527911.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_006527911.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:186298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  3. XM_006527847.3XP_006527910.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_006527910.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:186298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  4. XM_006527853.3XP_006527916.1  NF-kappa-B essential modulator isoform X4

    See identical proteins and their annotated locations for XP_006527916.1

    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000109764.2, OTTMUSP00000021357, ENSMUST00000114129.8, OTTMUST00000047321
    Conserved Domains (3) summary
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:167279
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  5. XM_006527850.2XP_006527913.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527913.1

    UniProtKB/Swiss-Prot
    O88522
    Related
    ENSMUSP00000109763.1, OTTMUSP00000021358, ENSMUST00000114128.7, OTTMUST00000047322
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  6. XM_006527851.2XP_006527914.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_006527914.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  7. XM_006527849.2XP_006527912.1  NF-kappa-B essential modulator isoform X2

    Conserved Domains (3) summary
    cd09803
    Location:257343
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:50117
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:174286
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  8. XM_011247527.2XP_011245829.1  NF-kappa-B essential modulator isoform X3

    See identical proteins and their annotated locations for XP_011245829.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (3) summary
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:168280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
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