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FITM1 fat storage inducing transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 161247, updated on 21-Dec-2019

Summary

Official Symbol
FITM1provided by HGNC
Official Full Name
fat storage inducing transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:33714
See related
Ensembl:ENSG00000139914 MIM:612028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIT1
Summary
FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]
Expression
Biased expression in heart (RPKM 28.4), prostate (RPKM 3.1) and 3 other tissues See more
Orthologs

Genomic context

See FITM1 in Genome Data Viewer
Location:
14q12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24131466..24132849)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24600675..24602058)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene neural retina leucine zipper Neighboring gene phosphoenolpyruvate carboxykinase 2, mitochondrial Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene proteasome activator subunit 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene microRNA 7703 Neighboring gene proteasome activator subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DCAF11

Homology

Clone Names

  • MGC46490

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid droplet organization TAS
Traceable Author Statement
more info
 
lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sequestering of triglyceride ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fat storage-inducing transmembrane protein 1
Names
fat-inducing protein 1
fat-inducing transcript 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203402.2NP_981947.1  fat storage-inducing transmembrane protein 1

    See identical proteins and their annotated locations for NP_981947.1

    Status: VALIDATED

    Source sequence(s)
    BC139911
    Consensus CDS
    CCDS9611.1
    UniProtKB/Swiss-Prot
    A5D6W6
    Related
    ENSP00000267426.5, ENST00000267426.5
    Conserved Domains (1) summary
    pfam10261
    Location:80264
    Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24131466..24132849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    432444..433827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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