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DCAF11 DDB1 and CUL4 associated factor 11 [ Homo sapiens (human) ]

Gene ID: 80344, updated on 5-Apr-2020

Summary

Official Symbol
DCAF11provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 11provided by HGNC
Primary source
HGNC:HGNC:20258
See related
Ensembl:ENSG00000100897 MIM:613317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL014; WDR23; PRO2389
Summary
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in liver (RPKM 25.7), small intestine (RPKM 25.5) and 25 other tissues See more
Orthologs

Genomic context

See DCAF11 in Genome Data Viewer
Location:
14q12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24114697..24125242)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24583906..24594451)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene copine 6 Neighboring gene neural retina leucine zipper Neighboring gene phosphoenolpyruvate carboxykinase 2, mitochondrial Neighboring gene fat storage inducing transmembrane protein 1 Neighboring gene proteasome activator subunit 1 Neighboring gene ER membrane protein complex subunit 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with DDB1 and CUL4 associated factor 11 (DCAF11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with DDB1 and CUL4 associated factor 11 (DCAF11; WDR23) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FITM1

Homology

Clone Names

  • DKFZp779A1629

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 11
Names
WD repeat domain 23
WD repeat-containing protein 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163484.1NP_001156956.1  DDB1- and CUL4-associated factor 11 isoform 1

    See identical proteins and their annotated locations for NP_001156956.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB209073, AK074296, AK094478, BC067132, BX406971, CD644652
    Consensus CDS
    CCDS9610.1
    UniProtKB/Swiss-Prot
    Q8TEB1
    UniProtKB/TrEMBL
    B3KSW2, Q59GN6
    Related
    ENSP00000452898.1, ENST00000559115.5
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:169511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_025230.5NP_079506.3  DDB1- and CUL4-associated factor 11 isoform 1

    See identical proteins and their annotated locations for NP_079506.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AB209073, AK074296, AK094478, BP245093, BX406971
    Consensus CDS
    CCDS9610.1
    UniProtKB/Swiss-Prot
    Q8TEB1
    UniProtKB/TrEMBL
    B3KSW2, Q59GN6
    Related
    ENSP00000415556.3, ENST00000446197.7
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:169511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_181357.2NP_852002.1  DDB1- and CUL4-associated factor 11 isoform 2

    See identical proteins and their annotated locations for NP_852002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AB209073, AK057636, AK094478, BX406971, DB212727
    Consensus CDS
    CCDS41929.1
    UniProtKB/Swiss-Prot
    Q8TEB1
    UniProtKB/TrEMBL
    B3KSW2, Q59GN6
    Related
    ENSP00000380146.4, ENST00000396941.8
    Conserved Domains (3) summary
    COG2319
    Location:143505
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:195237
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:143485
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_028099.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in a 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB209073, AL136295, BP245093, BX406971
    Related
    ENST00000557802.5
  2. NR_028100.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5'-most exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB209073, AK094478, AK296742, AL136295, BX406971, DB003266

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24114697..24125242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    415675..426220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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