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DAPK1 death associated protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 1612, updated on 6-Nov-2022

Summary

Official Symbol
DAPK1provided by HGNC
Official Full Name
death associated protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:2674
See related
Ensembl:ENSG00000196730 MIM:600831; AllianceGenome:HGNC:2674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAPK; ROCO3
Summary
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

See DAPK1 in Genome Data Viewer
Location:
9q21.33
Exon count:
30
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87497228..87708634)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (99650695..99862240)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90112143..90323549)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376127 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene hESC enhancers GRCh37_chr9:90024569-90025224 and GRCh37_chr9:90025225-90025878 Neighboring gene ribosomal protein S29 pseudogene 18 Neighboring gene DAPK1 intronic transcript 1 Neighboring gene CTSL promoter region Neighboring gene CTSL 3' regulatory element Neighboring gene cathepsin L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
EBI GWAS Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781I035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of DAPK1-calmodulin complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
death-associated protein kinase 1
Names
DAP kinase 1
NP_001275658.1
NP_001275659.1
NP_001275660.1
NP_004929.2
XP_005251814.1
XP_016869849.1
XP_047278842.1
XP_047278843.1
XP_047278844.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029883.1 RefSeqGene

    Range
    5027..215794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288729.2NP_001275658.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355, Q9BTL8
    Related
    ENSP00000484267.1, ENST00000622514.4
    Conserved Domains (5) summary
    PLN03192
    Location:515768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367639
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001288730.2NP_001275659.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AB208871, BC113660, BC143733, DC340223, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355, Q9BTL8
    UniProtKB/TrEMBL
    Q59H88
    Related
    ENSP00000417076.1, ENST00000472284.5
    Conserved Domains (5) summary
    PLN03192
    Location:515768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367639
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001288731.2NP_001275660.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL160279, AL161787, AL591852, BC113660, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355, Q9BTL8
    Related
    ENSP00000350785.5, ENST00000358077.9
    Conserved Domains (5) summary
    PLN03192
    Location:515768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367639
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_004938.4NP_004929.2  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_004929.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK295119, BC113660, BG110813, CX872304, DR002874, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355, Q9BTL8
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000386135.3, ENST00000408954.8
    Conserved Domains (5) summary
    PLN03192
    Location:515768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367639
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    87497228..87708634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422887.1XP_047278843.1  death-associated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9BTL8
  2. XM_047422886.1XP_047278842.1  death-associated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9BTL8
  3. XM_005251757.5XP_005251814.1  death-associated protein kinase 1 isoform X3

    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
  4. XM_047422888.1XP_047278844.1  death-associated protein kinase 1 isoform X4

  5. XM_017014360.2XP_016869849.1  death-associated protein kinase 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    99650695..99862240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)