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DAPK1 death associated protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 1612, updated on 14-Oct-2018

Summary

Official Symbol
DAPK1provided by HGNC
Official Full Name
death associated protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:2674
See related
Ensembl:ENSG00000196730 MIM:600831; Vega:OTTHUMG00000020150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAPK; ROCO3
Summary
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
Orthologs

Genomic context

See DAPK1 in Genome Data Viewer
Location:
9q21.33
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (87497228..87708634)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90112601..90323566)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376127 Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene ribosomal protein S29 pseudogene 18 Neighboring gene DAPK1 intronic transcript 1 Neighboring gene eukaryotic translation initiation factor 3 subunit J pseudogene Neighboring gene cathepsin L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
NHGRI GWA Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Bladder Cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, organism-specific biosystem (from KEGG)
    Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, conserved biosystem (from KEGG)
    Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
    IFN-gamma pathway, organism-specific biosystem
    IFN-gamma pathway
  • Ligand-independent caspase activation via DCC, organism-specific biosystem (from REACTOME)
    Ligand-independent caspase activation via DCC, organism-specific biosystemIn the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781I035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
death-associated protein kinase 1
Names
DAP kinase 1
NP_001275658.1
NP_001275659.1
NP_001275660.1
NP_004929.2
XP_005251814.1
XP_016869849.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029883.1 RefSeqGene

    Range
    4841..215794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288729.1NP_001275658.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355
    Related
    ENSP00000484267.1, ENST00000622514.4
    Conserved Domains (5) summary
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl26073
    Location:515768
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001288730.1NP_001275659.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AB208871, BC113660, BC143733, DC340223, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355
    UniProtKB/TrEMBL
    Q59H88
    Related
    ENSP00000417076.1, OTTHUMP00000216191, ENST00000472284.5, OTTHUMT00000356841
    Conserved Domains (5) summary
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl26073
    Location:515768
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001288731.1NP_001275660.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL160279, AL161787, AL591852, BC113660, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355
    Related
    ENSP00000350785.5, OTTHUMP00000021604, ENST00000358077.9, OTTHUMT00000052942
    Conserved Domains (5) summary
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl26073
    Location:515768
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_004938.3NP_004929.2  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_004929.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK295119, AL161787, BC113660, BG110813, CX872304, DR002874, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    P53355
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000386135.3, OTTHUMP00000216192, ENST00000408954.7, OTTHUMT00000356843
    Conserved Domains (5) summary
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
    cl26073
    Location:515768
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    87497228..87708634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251757.4XP_005251814.1  death-associated protein kinase 1 isoform X2

    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:505629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:412442
    ANK; ANK repeat [structural motif]
  2. XM_017014360.1XP_016869849.1  death-associated protein kinase 1 isoform X1

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