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DGKA diacylglycerol kinase alpha [ Homo sapiens (human) ]

Gene ID: 1606, updated on 7-Dec-2018

Summary

Official Symbol
DGKAprovided by HGNC
Official Full Name
diacylglycerol kinase alphaprovided by HGNC
Primary source
HGNC:HGNC:2849
See related
Ensembl:ENSG00000065357 MIM:125855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK; DAGK1; DGK-alpha
Summary
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Expression
Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues See more
Orthologs

Genomic context

See DGKA in Genome Data Viewer
Location:
12q13.2
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (55931091..55954023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56324946..56347811)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase pi 1 pseudogene 1 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12821, MGC42356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase alpha
Names
80 kDa diacylglycerol kinase
DAG kinase alpha
diacylglycerol kinase, alpha 80kDa
diglyceride kinase alpha
NP_001336.2
NP_001337962.1
NP_001337963.1
NP_001337964.1
NP_001337965.1
NP_001337966.1
NP_001337967.1
NP_001337968.1
NP_001337969.1
NP_958852.1
NP_958853.1
NP_963848.1
XP_005268746.1
XP_011536295.1
XP_011536297.1
XP_016874389.1
XP_016874390.1
XP_016874391.1
XP_016874392.1
XP_016874393.1
XP_016874394.1
XP_016874395.1
XP_016874396.1
XP_016874397.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345.5NP_001336.2  diacylglycerol kinase alpha isoform a

    See identical proteins and their annotated locations for NP_001336.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
    Source sequence(s)
    BC023523, BC031870, BM836118, BQ943057
    Consensus CDS
    CCDS8896.1
    UniProtKB/Swiss-Prot
    P23743
    UniProtKB/TrEMBL
    A0A024RB23
    Related
    ENSP00000328405.5, ENST00000331886.9
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  2. NM_001351033.1NP_001337962.1  diacylglycerol kinase alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.
    Source sequence(s)
    AC025162, BC031870
    Consensus CDS
    CCDS8896.1
    Related
    ENSP00000450359.1, ENST00000551156.5
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  3. NM_001351034.1NP_001337963.1  diacylglycerol kinase alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
    Source sequence(s)
    AC025162
    Consensus CDS
    CCDS8896.1
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  4. NM_001351035.1NP_001337964.1  diacylglycerol kinase alpha isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (b).
    Source sequence(s)
    AC025162
    Conserved Domains (5) summary
    smart00045
    Location:558739
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:416537
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:152221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:244292
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:44148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  5. NM_001351036.1NP_001337965.1  diacylglycerol kinase alpha isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform c.
    Source sequence(s)
    AC025162
    Conserved Domains (4) summary
    smart00045
    Location:379560
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:237358
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:65113
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl08302
    Location:142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  6. NM_001351037.1NP_001337966.1  diacylglycerol kinase alpha isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform c.
    Source sequence(s)
    AC025162
    Conserved Domains (4) summary
    smart00045
    Location:379560
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:237358
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:65113
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl08302
    Location:142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  7. NM_001351038.1NP_001337967.1  diacylglycerol kinase alpha isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform d.
    Source sequence(s)
    AC025162
    Conserved Domains (2) summary
    smart00045
    Location:166347
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:24145
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
  8. NM_001351039.1NP_001337968.1  diacylglycerol kinase alpha isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform d.
    Source sequence(s)
    AC025162
    Conserved Domains (2) summary
    smart00045
    Location:166347
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:24145
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
  9. NM_001351040.1NP_001337969.1  diacylglycerol kinase alpha isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform d.
    Source sequence(s)
    AC025162
    Conserved Domains (2) summary
    smart00045
    Location:166347
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:24145
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
  10. NM_201444.2NP_958852.1  diacylglycerol kinase alpha isoform a

    See identical proteins and their annotated locations for NP_958852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.
    Source sequence(s)
    AF064768, AI815678, BC023523, BC031870, BM910598
    Consensus CDS
    CCDS8896.1
    UniProtKB/Swiss-Prot
    P23743
    UniProtKB/TrEMBL
    A0A024RB23
    Related
    ENSP00000377703.1, ENST00000394147.5
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  11. NM_201445.1NP_958853.1  diacylglycerol kinase alpha isoform a

    See identical proteins and their annotated locations for NP_958853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.
    Source sequence(s)
    AF064768, BC023523, BC031870, BF448612
    Consensus CDS
    CCDS8896.1
    UniProtKB/Swiss-Prot
    P23743
    UniProtKB/TrEMBL
    A0A024RB23
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  12. NM_201554.1NP_963848.1  diacylglycerol kinase alpha isoform a

    See identical proteins and their annotated locations for NP_963848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.
    Source sequence(s)
    AF064768, BC023523, BC031870, BF448612
    Consensus CDS
    CCDS8896.1
    UniProtKB/Swiss-Prot
    P23743
    UniProtKB/TrEMBL
    A0A024RB23
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RNA

  1. NR_147026.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025162
    Related
    ENST00000402956.7
  2. NR_147027.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025162

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    55931091..55954023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018901.2XP_016874390.1  diacylglycerol kinase alpha isoform X2

  2. XM_011537993.2XP_011536295.1  diacylglycerol kinase alpha isoform X4

    See identical proteins and their annotated locations for XP_011536295.1

    UniProtKB/Swiss-Prot
    P23743
    UniProtKB/TrEMBL
    A0A024RB23
    Conserved Domains (5) summary
    smart00045
    Location:520701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  3. XM_011537995.2XP_011536297.1  diacylglycerol kinase alpha isoform X5

    See identical proteins and their annotated locations for XP_011536297.1

    Conserved Domains (4) summary
    smart00045
    Location:408589
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:266387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:94142
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl08302
    Location:3071
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_017018907.1XP_016874396.1  diacylglycerol kinase alpha isoform X2

  5. XM_017018902.1XP_016874391.1  diacylglycerol kinase alpha isoform X2

  6. XM_017018903.1XP_016874392.1  diacylglycerol kinase alpha isoform X2

  7. XM_017018906.2XP_016874395.1  diacylglycerol kinase alpha isoform X2

  8. XM_017018904.1XP_016874393.1  diacylglycerol kinase alpha isoform X2

  9. XM_005268689.2XP_005268746.1  diacylglycerol kinase alpha isoform X5

    See identical proteins and their annotated locations for XP_005268746.1

    Conserved Domains (4) summary
    smart00045
    Location:408589
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:266387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:94142
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl08302
    Location:3071
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  10. XM_017018905.1XP_016874394.1  diacylglycerol kinase alpha isoform X2

  11. XM_017018900.1XP_016874389.1  diacylglycerol kinase alpha isoform X1

  12. XM_017018908.1XP_016874397.1  diacylglycerol kinase alpha isoform X3

RNA

  1. XR_002957296.1 RNA Sequence

  2. XR_002957293.1 RNA Sequence

  3. XR_001748602.1 RNA Sequence

  4. XR_002957294.1 RNA Sequence

  5. XR_002957295.1 RNA Sequence

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