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Ifnar1 interferon (alpha and beta) receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 15975, updated on 27-Feb-2024

Summary

Official Symbol
Ifnar1provided by MGI
Official Full Name
interferon (alpha and beta) receptor 1provided by MGI
Primary source
MGI:MGI:107658
See related
Ensembl:ENSMUSG00000022967 AllianceGenome:MGI:107658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifar; Ifrc; Ifnar; Infar
Summary
Enables type I interferon binding activity and type I interferon receptor activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and response to lipopolysaccharide. Acts upstream of or within several processes, including defense response to virus; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ifnar1 in Genome Data Viewer
Location:
16 C3.3; 16 52.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91281016..91307411)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91485032..91510523)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9937 Neighboring gene STARR-positive B cell enhancer ABC_E10924 Neighboring gene predicted gene, 46562 Neighboring gene RIKEN cDNA A930006K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E3172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91470747-91470930 Neighboring gene STARR-seq mESC enhancer starr_41478 Neighboring gene STARR-seq mESC enhancer starr_41479 Neighboring gene STARR-positive B cell enhancer ABC_E5561 Neighboring gene cell division cycle 20 homolog pseudogene Neighboring gene microRNA 6367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JAK pathway signal transduction adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables interferon receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoribosylamine-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables type I interferon binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type I interferon receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type I interferon receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables type I interferon receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables type I interferon receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to interferon-alpha IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interferon alpha/beta receptor 1
Names
IFN-R-1
IFN-alpha/beta receptor 1
IFN-alpha/betaR
INF-a receptor
type I interferon receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010508.2NP_034638.2  interferon alpha/beta receptor 1 precursor

    See identical proteins and their annotated locations for NP_034638.2

    Status: VALIDATED

    Source sequence(s)
    AC132272, AC150035, BC052429, BE955685, CA322032
    Consensus CDS
    CCDS28326.1
    UniProtKB/Swiss-Prot
    P33896, Q80UJ3
    UniProtKB/TrEMBL
    Q3UFX4
    Related
    ENSMUSP00000023689.5, ENSMUST00000023689.11
    Conserved Domains (2) summary
    pfam09294
    Location:126224
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:335422
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91281016..91307411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_384931.4 RNA Sequence