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IFNAR1 interferon alpha and beta receptor subunit 1 [ Homo sapiens (human) ]

Gene ID: 3454, updated on 4-Oct-2020

Summary

Official Symbol
IFNAR1provided by HGNC
Official Full Name
interferon alpha and beta receptor subunit 1provided by HGNC
Primary source
HGNC:HGNC:5432
See related
Ensembl:ENSG00000142166 MIM:107450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
Summary
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in thyroid (RPKM 14.1), urinary bladder (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See IFNAR1 in Genome Data Viewer
Location:
21q22.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33324395..33359864)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34696748..34732129)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene IL10RB divergent transcript Neighboring gene interleukin 10 receptor subunit beta Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B Neighboring gene RPS5 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Seven-day cultured macrophages treated with HIV-1 gp120 exhibit higher levels of type I IFN receptors than that of 1-day cultured monocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type I interferon binding ISS
Inferred from Sequence or Structural Similarity
more info
 
type I interferon receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-alpha ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to virus TAS
Traceable Author Statement
more info
PubMed 
type I interferon signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interferon alpha/beta receptor 1
Names
CRF2-1
IFN-R-1
IFN-alpha/beta receptor 1
alpha-type antiviral protein
beta-type antiviral protein
cytokine receptor class-II member 1
cytokine receptor family 2 member 1
interferon (alpha, beta and omega) receptor 1
interferon receptor 1
interferon-alpha/beta receptor alpha chain
interferon-beta receptor 1
type I interferon receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000629.3NP_000620.2  interferon alpha/beta receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_000620.2

    Status: REVIEWED

    Source sequence(s)
    AK123813, AP000298, BC021825, BC035603, BG116121, BG548299, BX537636, CA309858, J03171, R15745
    Consensus CDS
    CCDS13624.1
    UniProtKB/Swiss-Prot
    P17181
    Related
    ENSP00000270139.3, ENST00000270139.8
    Conserved Domains (2) summary
    pfam09294
    Location:126224
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:25114
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001384498.1NP_001371427.1  interferon alpha/beta receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  3. NM_001384499.1NP_001371428.1  interferon alpha/beta receptor 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  4. NM_001384500.1NP_001371429.1  interferon alpha/beta receptor 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  5. NM_001384501.1NP_001371430.1  interferon alpha/beta receptor 1 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  6. NM_001384502.1NP_001371431.1  interferon alpha/beta receptor 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  7. NM_001384503.1NP_001371432.1  interferon alpha/beta receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
  8. NM_001384504.1NP_001371433.1  interferon alpha/beta receptor 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP000296, AP000297, AP000298
    Related
    ENSP00000498654.1, ENST00000652450.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    33324395..33359864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529552.2XP_011527854.1  interferon alpha/beta receptor 1 isoform X2

    Related
    ENSP00000498491.1, ENST00000652513.1
    Conserved Domains (2) summary
    pfam09294
    Location:126224
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:25114
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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